Home  >  Health Check  >  Vaccines: A tale of the unexpected
Health Check
Vaccines: A tale of the unexpected
Health Check
Mar 1, 2023

We delve into the science of how some vaccines could have unexpected effects beyond their intended target. They are called “non-specific effects” and we are only just at the beginning of our understanding despite scientists documenting this curious biological phenomenon more than 100 years ago.

One of the earliest vaccines to be studied was the Bacillus Calmette-Guérin vaccine for Tuberculosis, better known as the BCG. Professor Christine Stabell-Benn gives us a history lesson and brings us up to date with her team’s research at the Bandim Health Project in Guinea-Bissau, Western Africa. Also in the programme we hear about a new device for fixing bones being trialled in Gaza and Sri Lanka – and already in use in Ukraine. We hear from surgeons about what kind of patients they are treating and from UK researchers on hopes it will offer a low-cost, easy-to-make alternative in countries where there are shortages of these fixators.

Our studio guest this week is BBC News health and science journalist Philippa Roxby who talks us through the latest after an 11-year-old girl in Cambodia died from the H5N1 strain of bird flu. Plus, we look at new studies on long Covid and how much exercise we should be aiming to do each day.

Presenter: Claudia Hammond Producer: Gerry Holt and Emily Knight

More Episodes


Mar 25, 2026
Antimicrobial resistance in conflict zones

For the last few weeks, the news has been dominated by the situation in the Middle East. Joining Claudia Hammond is BBC Health Correspondent James Gallagher who speaks with Dr Antoine Abou Fayad, a microbiologist and medicinal chemist based in Beirut, Lebanon. He reveals that war, just like the ongoing conflict in the Middle East, provides the perfect storm to accelerate the spread of multidrug-resistant infections. And nobody is safe.

Following the recent meningitis B outbreak in the UK which has killed two people and led to the rollout of vaccines and preventative antibiotics, Claudia and James discuss how meningitis outbreaks are dealt with in the ‘meningitis belt’ - an area stretching across 26 sub-Saharan African countries and talk about a new vaccine aiming to stop deadly meningitis epidemics which has been confirmed to be safe following analysis of vaccination campaigns in Nigeria and Niger.

And India's snakebite crisis is killing near sixty thousand people every year, about six people every hour. Journalist Chhavi Sachdev joins us to discuss the progress of India’s National Action Plan to tackle snakebite envenoming which launched two years ago. Also, what time of day do you exercise? Well, a new study using Fitbit-derived heart rate data has found that people who regularly exercised early in the morning were significantly less likely to have coronary artery disease, high blood pressure, Type 2 diabetes or obesity compared with people who exercised later in the day.

Presenter: Claudia Hammond Producer: Jonathan Blackwell


26min 28sec

Mar 18, 2026
Does your home country impact your cancer risk?

North Korean defectors and lifelong South Korean residents have significantly different cancer rates, despite their genetic similarities; new research finds. Presenter Laura Foster unpacks this study, explaining what it tells us about how upbringing and environment contribute to different cancer rates, and how migration can change these risks.

A new study has found GLP-1s – drugs typically used to treat diabetes and obesity – could have an unexpected benefit for patients dealing with substance abuse disorders. Laura speaks with Ziyad Al-Aly, a clinical epidemiologist and Veterans Affairs physician at Washington University in St Louis to understand what this could mean for treating drug and alcohol addictions, and what questions still need answers before this treatment can be rolled out.

Last weekend, Kenya’s National Environment Management Authority rolled out new waste management rules to better dispose of products containing plastic, but the new laws are expected to increase the price of sanitary pads by 20%. Global health reporter based in Nairobi, Dorcas Wangira joins Laura to unpack what these policies mean for the accessibility of sanitary products, and what alternative solutions are needed to balance access with environmental impact. They also discuss how a drug to treat Parkinson’s disease can be made from waste plastic bottles using a pioneering method.

And Jane Chambers reports from Peru about the growing prevalence of anaemia, speaking to local healthcare workers about what steps families can be taken to help their children recover.

Presenter: Laura Foster Producers: Jonathan Blackwell and Georgia Christie


26min 28sec

Vaccines: A tale of the unexpected

--:--
--:--