Home  >  Health Check  >  Gene therapy hope for sickle cell patients
Health Check
Gene therapy hope for sickle cell patients
Health Check
Jan 26, 2022

Positive results for a handful of patients on a trial in the United States offers hope for the millions of people around the world living with sickle cell disease. Doctors say the gene-editing therapy literally 'turns back the clock' by reducing the number of red blood cells that are sickle-shaped and increasing the type that a baby has, which can carry more oxygen around the body. Other cheaper, more widely-available medications can work, but we hear how the health of sickle cell patients depends on where they live. After two years of caring for patients with Covid-19, many healthcare workers are exhausted. This week’s guest, Graham Easton, who is Professor of Communication Skills at Barts and The Royal London Hospital, explains how mistakes can happen when doctors carry out repetitive tasks when they are tired. Could changing your asthma inhaler be better for you and the planet? We hear from Caroline and her son Sebastian, who found that switching to dry-powder inhalers transformed their lives.

Presenter: Claudia Hammond Producer: Paula McGrath and Samara Linton

(Picture: Scientist analysing a blood sample in a laboratory. Photo credit: Krisanapong Detraphiphat/Getty Images.)

More Episodes

Jun 24, 2026
Lack of evidence most IVF ‘add-ons’ improve fertility

Many people with infertility use in vitro fertilisation (IVF), however the probability of having a baby following IVF is only approximately 30-40% per cycle and decreases significantly with age. It can be a lengthy and expensive process. Providers sometimes offer ‘add-ons’, additional treatments that they claim could help patients conceive, which are themselves also usually expensive. In Australia, New Zealand and the United Kingdom more than 70% of patients pay for at least one of these add-ons. A new review published in The Lancet Obstetrics, Gynaecology, & Women’s Health journal has found that evidence on the benefits of these add-on treatments is unclear. Claudia Hammond speaks to Dr Sarah Lensen, Senior Research Fellow in the Department of Obstetrics, Gynaecology and Newborn Health at the University of Melbourne.

Joining Claudia from Ghana is genito-urinary consultant and HIV expert, Vanessa Apea. Claudia and Vanessa discuss a draft African Charter on Family, Sovereignty and Values, which claims that comprehensive sex education, as well as a range of sexual and reproductive health rights, are a threat to African families from foreign ideologies.

They also discuss a report from the Office of Inspector General of US Agency for International Development (USAID) which reveals that President Donald Trump’s administration has spent hundreds of thousands of dollars in storage and transportation costs for $9.7 million worth of contraceptives that are being stored in Belgium rather than distributed to the various low-income countries they were intended for. Many of the withheld contraceptives are now expired or unusable due to their removal from temperature-controlled storage.

We also hear from Health Check reporter Jane Chambers in the Chilean city of Valdivia, where wetlands are part of everyday life—and increasingly, part of people’s health. And we hear how faecal-microbiome transplants could improve the efficacy of some antidepressants in patients with major depressive disorder.

Presenter: Claudia Hammond Producers: Jonathan Blackwell & Georgia Christie


26min 29sec



Gene therapy hope for sickle cell patients

--:--
--:--