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How far could gene editing go?
CrowdScience
May 6, 2022

Humans now have the ability to directly change their DNA, and gene-editing tool CRISPR has led to a new era in gene-editing. CrowdScience listener ‘Bones’ wants to know how gene-editing is currently being used and what might be possible in the future.

Gene-editing offers huge opportunities for the prevention and treatment of human diseases, and trials are currently underway in a wide range of diseases like sickle cell anaemia. CrowdScience presenter Caroline Steel finds out about some of the most promising work tackling disease before turning to consider the possibilities of using gene editing to enhance ourselves.

Will we be able to extend human longevity, swap our eye colour or improve athletic performance? And even if we can do all these things, should we?

As scientists push the boundaries of gene-editing and some people are DIY experimenting on themselves with CRISPR, we discuss the practical and ethical challenges facing this promising but potentially perilous area of science.

Produced by Melanie Brown and presented by Caroline Steel for the BBC World Service Contributors: Prof George Church Prof Waseem Qasim Jimi Olaghere Josiah Zayner Prof Joyce harper Prof Julian Suvalescu

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Apr 5, 2024
How many people have ever existed?

Today there are over eight billion people on Earth. That’s an awe-inspiring figure… but how does it compare to the vast numbers who came before us? Listener Alpha wants to know how many people have ever existed, so CrowdScience sets out to do a historical headcount.

The Population Reference Bureau in the USA estimated this number back in the 90s, and have been updating their calculations ever since. Demographer Toshiko Kaneda explains how their model works, the assumptions it makes – and the huge uncertainties around the number it comes out with.

We first need a date for when ‘humans’ first began, so Caroline travels to the Natural History Museum in London to meet human evolution expert Chris Stringer, and marvel at his collection of replica fossil skulls. Chris demonstrates how to distinguish our species, Homo sapiens, from other species like Neanderthals. When did these species first appear - and which of them count as human?

And once you know where to start the clock, how do you estimate the numbers of people alive at different points in history? For a population demographer like Walter Scheidel, it helps that some ancient civilisations kept detailed censuses, a few of which have survived to the present day. Caroline and Walter pour over one of these census fragments, and learn how to combine them with other archaeological clues to get some very rough numbers.

And finally: what does the future of our population look like? Poonam Muttreja from the Population Foundation of India discusses developments in the world’s most populous country, as well as the big demographic trends ahead for humanity.

Presenter: Caroline Steel Producer: Phil Sansom Additional Recording: Umaru Fofana Editor: Cathy Edwards Production Co-ordinator: Connor Morgans Studio Manager: Sue Maillot

Featuring: Toshiko Kaneda, Technical Director of Demographic Research, Population Reference Bureau Chris Stringer, Research Leader in Human Evolution, Natural History Museum London Walter Scheidel, Professor of Classics and History, Stanford University Poonam Muttreja, Executive Director, Population Foundation of India


26min 28sec


Mar 22, 2024
Do animals have anxious habits like us?

Many of us have habits that calm us down in times of stress. Things we find deeply comforting, like sucking our thumb or biting our nails. We might not even be aware we’re doing them, but they play a fundamental role in helping us regulate our emotions.

Our question this week comes from CrowdScience listener and nail-biter, Ash. He wants to know where these habits come from. And since his pet dog is also a nail-biter: do we share these traits with other animals?

Recently, a video of a mouse cleaning up a man’s shed took the internet by storm. Was this a house-proud mouse, or was it the animal's way of making sense of a frenetic environment? An emerging field of scientists focusing on animal behaviour and emotions help us shed some light on such questions.

Along the way we meet a dog training specialist, learn what a sniffari is, go for playtime with a thumb-sucking otter, and visit an OCD clinic. We’ll also be getting tips on how to give your pets the best home environment, and meet an animal enrichment officer in South Africa, who knows how to spot the signs of an unhelpful habit developing.

Contributors: Karolina Westlund, Ethologist, Stockholm University and ILLIS Ben Terry, CBT Therapist, Priory Hospital North London Karin Pienaar, Animal Behaviourist, COAPE International Candice Ward, Animal Behaviourist, Johannesburg Zoo

Jaak Panksepp clip: The science of emotions: Jaak Panksepp at TEDxRainier

Producer: Robbie Wojciechowski Presenter: Alex Lathbridge Editor: Cathy Edwards Production co-ordinator: Connor Morgans Additional recording by Elna Schutz

(Photo: Portrait of border collie puppy biting a curtain. Credit: Rawlstock/Getty Images)


27min 29sec


How far could gene editing go?

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