Multiple Sclerosis (MS) is a neurological disease which can lead to loss of mobility and vision. Almost 3 million people worldwide are affected by it. There is no cure, but attempts are being made to accelerate the healing process with treatments to restore what the disease has damaged.

At the same time, scientists have recently discovered a link between MS and a common virus that the majority of us carry in our bodies. It had been known for years that there was a link between Multiple Sclerosis and Epstein-Barr virus (EBV). But then, a study finally proved the link.

Now, trials are underway on potential vaccines against EBV and scientists are hopeful that this could be a gateway to preventing MS.

This week on the Inquiry we are asking: Are we close to a breakthrough for Multiple Sclerosis?

Contributors:

Tim Coetzee, Chief Advocacy, Services & Science Officer for the National MS Society, US Tjalf Ziemssen, Professor of Clinical Neuroscience and Head of the Multiple Sclerosis Center and Neuroimmunological Laboratory, University Clinic Carl-Gustav Carus, Germany Jeffrey Huang, Associate Professor of Biology, Georgetown University, US Claire Shannon-Lowe, Associate Professor in Virology, Institute of Immunology and Immunotherapy at the University of Birmingham, UK

Production team:

Presenter: Tanya Beckett Producer: Matt Toulson Researcher: Ajai Singh Editor: Tara McDermott Studio Manager: Hal Haines Production Co-ordinator: Liam Morrey

Image Credit: Shidlovski\Getty

For centuries chocolate has had a global appeal, the key ingredient of this confectionery is derived from the dried and fully fermented seed of the Theobroma cacao, whose origins began in northern Amazonia. From this tree, both cocoa solids and cocoa butter can be extracted to form the basis of chocolate.

Today, it’s the West African countries of Côte d’Ivoire and Ghana that produce the bulk of the world’s supply of cocoa beans. But in recent years hotter temperatures and shifts in rainfall patterns have impacted cocoa harvests particularly in this region. And now the global price of this key ingredient has roughly doubled since the start of last year, fuelling concern that demand could outweigh supply. Cocoa farming itself is mainly small scale and these farmers are at the bottom end of the value chain when it comes to profits. But whilst many of the major chocolate manufacturers do invest in the industry, with support for improved planting and harvesting techniques, farming sustainably is just one of a number of challenges that these small farmers face.

So on this week’s Inquiry, we’re asking ‘Is climate change impacting chocolate production?’

Contributors: Dr Katie Sampeck, British Academy Global Professor of Historical Archaeology, University of Reading, England Philip Antwi-Agyei, Associate Professor, Department of Environmental Science, Kwame Nkrumah University of Science and Technology, Ghana Steffany Bermúdez, Policy Advisor, International Institute for Sustainable Development (IISD), Canada Yunusa Abubakar, Project Manager, International Cocoa Organisation (ICCO), Côte d’Ivoire

Presenter: Charmaine Cozier Producer: Jill Collins Researcher: Matt Toulson Editor: Tara McDermott Technical Producer: Hal Haines Production Co-ordinator: Liam Morrey

Image by grafvision via Getty Images

In February this year, El Salvador's president Nayib Bukele won re-election with nearly 85% of the vote. His flagship policy after he came to power in 2019 has been the mass arrest of thousands of alleged gang members, mainly young men.

It is estimated that over 100,000 people are now behind bars as part of his crime crackdown. The round-ups have been hugely popular with El Salvador's people as it has improved security and neighbouring countries are taking note.

But critics say following Bukele's approach could threaten democracy, not just in El Salvador but across the continent. So on this week’s Inquiry, we’re asking: Will neighbouring countries follow El Salvador's lead on crime?

Contributors: Carlos Dada, director of El Faro, an online newspaper based in El Salvador Katherine Saunders-Hastings, a lecturer in Latin American Studies at the University of London's Institute of the Americas. Will Freeman, Fellow for Latin American Studies at the Council on Foreign Relations, New York. Monica Pachon , a political scientist and professor at the University of the Andes in Bogotá, Colombia.

Presenter: David Baker Producer: Farhana Haider Journalism Researcher: Matt Toulson Editor: Tara McDermott Technical Producer: Nicky Edwards Production Co-ordinator: Tim Fernley and Liam Morrey

Image Credit: Alex Peña / Stringer via Getty Images

More than half of the world’s population currently lives in cities, and by 2050, the UN estimates that figure will rise to nearly 7 in 10 people. The world is also getting hotter, with heatwaves and wildfires becoming increasingly common.

So how can we deal with the dual challenges of increasing urbanisation and extreme weather caused by climate change? Perhaps we should look downwards.

For millennia, humans have taken refuge underground from the elements, predators and from war. Even today, bomb shelters exist under major cities like Beijing and Seoul. Many cities across the world have subway systems for easy transportation – and some are integrated seamlessly with below-ground business and shopping centres.

But what are the future challenges for urban planners and architects in this subterranean space, and how can we overcome the social stigma against those who live underground?

This week on the Inquiry, we ask: is our future underground?

Contributors: Martin Dixon, trustee of Subterranea Britannica, a society devoted to the study and investigation of man-made and man-used underground places. Jacques Besner, architect and urban planner; co-founder and general manager of Associated Research Centres for Urban Underground Spaces. Antonia Cornaro co-chair of ITACUS, the International Tunnelling and Underground Space Association's Committee on Underground Space. Professor Clara Irazábal, Director of the Urban Studies and Planning Program at the University of Maryland, USA.

Presenter: Tanya Beckett Producer: Ravi Naik Editor: Tara McDermott Researcher: Matt Toulson Production Coordinators : Janet Staples & Liam Morrey

Photo by BEHROUZ MEHRI via Getty Images