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Discovery
Genetic dreams, genetic nightmares
Discovery
Nov 22, 2021

Biologist Matthew Cobb presents the first episode in a series which looks at the 50-year history of genetic engineering, from the concerns around the first attempts at combining the DNA of one organism with the genes of another in 1971 to today’s gene editing technique known as CRISPR.

The first experiments to combine the DNA of two different organisms began at Stanford University in California in 1971. The revolutionary technique of splicing genes from one lifeform into another promised to be a powerful tool in understanding how our cells worked. It also offered the prospect of a new cheap means of manufacturing life-saving drugs – for example, by transferring the gene for human insulin into bacteria, growing those genetically engineered microbes in industrial vats and harvesting the hormone. A new industrial revolution based on biology looked possible.

At the same time some scientists and the public were alarmed by disastrous scenarios that genetic engineering might unleash. What if microbes engineered with toxin genes or cancer genes escaped from the labs and spread around the world?

In early 1974, responding to the public fears and their own disquiet about how fast the techniques were developing, the scientists leading this research revolution called for a global moratorium on genetic engineering experiments until the risks had been assessed.

This was followed by an historic meeting of 130 scientists from around the world in February 1975 in California. Its purpose was to decide if and how the genetic engineering research could be done safely. It was a rancorous affair but the Asilomar conference is held up as an idealist if imperfect example of scientists taking responsibility as they developed a powerful new technology.

(Picture: DNA molecule, Credit: KTS Design/Science Photo Library/Getty Images)

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Mar 21, 2024
The Evidence: The science of the menopause

Millions of women around the world experience the menopause each year; it’s an important milestone, which marks the end of their reproductive years.

But every individual's experience of it is personal and unique. In some cultures, there's a stigma about this life stage – it's viewed with trepidation and as something to be dreaded. In other cultures, it's considered to be a fresh start - a time of greater freedom when women no longer have to worry about their menstrual cycles.

In this edition, recorded at Northern Ireland Science Festival in Belfast, Claudia Hammond and her expert panel take a global look at the science of the menopause and debunk some myths along the way.

As Claudia and her guests navigate their way through the menopause maze, they look at the most recent academic research in this area. They also discuss the physical and psychological symptoms, the lifestyle changes women can make and the different treatments available, including Hormone Replacement Therapy.

Claudia also speaks to the American biological anthropologist who has dedicated an impressive 35 years of her life to studying the average age of the menopause in different countries - and finds out how hot flushes vary in different cultures. She also speaks to a doctor who is working hard to make women’s health less of a taboo subject in the community where she works. And she hears from a Professor of Reproductive Science who is setting up the UK's first menopause school.

Producer: Sarah Parfitt Co-ordinator: Siobhan Maguire Editor: Holly Squire Sound engineers: Andrew Saunderson and Bill Maul Mix engineer: Bob Nettles

Image used with permission of the Northern Ireland Science Festival


49min 26sec


Genetic dreams, genetic nightmares

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