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Researching pain, painlessly
Science In Action
Apr 10, 2025

Pain, particularly chronic pain, is hard to research. New therapeutics are hard to screen for. Patients are not all the same. Sergui Pascu and colleagues at Stanford university have been growing brain samples from stem cells. Then they began connecting different samples, specialised to represent different brain regions. This week they announce their most complex “assembloid” yet, one that even reacts to hot chilli, passing a signal from the sensory neurons through to the thinking bits. The hope is that it can provide insights on how pain, and potential painkillers, work.

Human brains are notoriously large, particularly infants. Whilst for primates the human pelvis is quite narrow, to allow us to walk and run on two legs. This notoriously makes childbirth, well, not as straightforward as most other species. This evolutionary “obstetric dilemma” has been debated for decades. Marianne Brasil, of Western Washington University, and colleagues, have published this week a huge study of contemporary human genes and anatomies available from the UK Biobank to shed some more light on this ongoing compromise.

Malta is an island in the Mediterranean no less than 80km from land. So how come Eleanor Scerri and colleagues have discovered archaeological evidence of hunter-gatherers living there from 8,500 years ago? And they didn’t just visit and leave. They stayed for perhaps a millennium before farming arrived. Maybe a rethink of what nautical capabilities our ancestors had in the deep past is needed?

A year ago, Science in Action gate-crashed a conference looking at plans for meeting the forthcoming arrival of asteroid Apophis in 2029. This year the meeting is in Tokyo, and Richard Binzel, emeritus professor of Astronomy at MIT, gives us an update on how the space agencies are hoping to collaborate to maximise the scientific value from what will be a global, visible, phenomenon in just 4 years. Is there enough time to get our collective wits together?

(Image: 3D illustration of Interconnected neurons with electrical pulses. Credit: Getty Images)

Presenter: Roland Pease Producer: Alex Mansfield Production co-ordinator: Josie Hardy

More Episodes
May 29, 2025
Thirteen months to a chip off the moon

China is aiming to join the small club of nations who have successfully returned scientific samples of asteroids for analysis on earth, teaching us more about how our and potentially other solar systems formed. Tianwen-2 launched successfully this week, bound for an asteroid known as Kamo‘oalewa, which sits in a very strange orbit of both the earth and the sun, making it a “quasi-satellite”.

Last year, scientists including Patrick Michel of the Côte d'Azur Observatory in France, published an intriguing suggestion that Kamo‘oalewa might in fact not be a conventional asteroid, but instead be a small piece of our moon that was ejected when the Giordano Bruno crater formed. In a little over a year from now, we might find out if that is right.

Do you have to hold text at arm’s length to read properly? Qiang Zhang, professor of physics at the University of Science and Technology of China, whose team recently published their demonstration of using a technique from radio astronomy but using optical light. Active Optical Interferometry involves using laser beams to achieve resolutions at distances far in excess of conventional imaging with lenses. As his team showed, and as Miles Paggett of Glasgow University admires, they managed to read newsprint sized letters at a distance of over 1.3km.

Finally, how did the Inca Empire write things down, and who did the writing? It has been thought that ornate threads of strings and baubles known as khipu are how records were made for business and administration, probably by a decimal code of knots in strings. But the exact purpose, nature and any meaning encoded therein, has eluded scholars for decades. Sabine Hyland, an anthropologist at the University of St Andrews, Scotland, has been studying them for years, and recently was granted access to the records of a village, only the fourth known, to have continued a form of the khipu tradition after the Spanish conquest to this day. She believes that they could even provide us in the modern world with valuable climate data.

Presenter: Roland Pease Producer: Alex Mansfield Production co-ordinator: Jazz George

(A Long March-3B Y110 carrier rocket carrying China's Tianwen-2 probe blasts off from the Xichang Satellite Launch Center on 29 May, 2025 in Sichuan Province of China. Credit: VCG/Getty Images)


35min 53sec

May 22, 2025
WHO Pandemic Agreement reached

This week, 124 countries agreed at the World Health Assembly in Geneva on measures aimed at preventing a future pandemic. The agreement very strongly favours a “One Health” approach, appreciating how so many potential pathogens originate in human-animal interactions. Still to agree on the terms of how to share pathogens and information with global science and vaccine researchers, eventually the treaty will need to be signed by at least 60 countries. But can the inequity between countries of the global south and north, and issues of intellectual property, be bridged?

A new study on origins of the Nigerian mpox epidemic points strongly to zoonotic crossovers and mobility of wildlife in West Africa. Edyth Parker of Redeemer’s University in Nigeria describes their phylogenetic tree.

Can the bovine form of H5N1 flu infect pigs, and could domestic pig populations then provide a crucible for further variants to develop? Jürgen Richt of Kansas State University and colleagues have been investigating. We need to keep up vigilance.

Lucy van Dorp of University College London, working with a consortium including London’s Crick Institute, has been looking at a moment in the past when human activity provided an opportunity for a bacterial human pathogen to change its lifestyle. According to their phylogenetic tree, the bacterium Borrelia recurrentis (which causes louse-borne relapsing fever in humans) adapted and moved from ticks to human body lice around about the same time as humans started using woollen clothing.

And Susan Lieberman, VP for International Policy at the Wildlife Conservation Society, was in the trenches of the Pandemic Agreement negotiations, and shares some of her hopes for its success.

Image: World Health Assembly formally adopts by consensus world's first Pandemic Agreement, Geneva, Switzerland - 20 May 2025 Image Credit: Magali Girardin via EPA-EFE/Shutterstock

Presenter: Roland Pease Producer: Alex Mansfield


40min 18sec

May 15, 2025
Vaccinating rabies’ reservoir dogs

In 2015, the World Health Organisation set the goal of eradicating rabies deaths from dog-bites to “Zero by 2030”. A team at the University of Glasgow and colleagues in Tanzania have been assessing the efficacy of dog vaccination schemes for reducing the numbers of human infections over the last 20 years. As Prof Katie Hampson tells Science in Action, in rural areas especially, vaccinating dog populations does work, but you need to keep at it, and not leave patches untouched. It should be funded as a public health measure, rather than a veterinary issue.

Last weekend, the remains of a failed 1972 Soviet mission to Venus landed harmlessly somewhere back on earth. As the BBC’s Maddie Molloy explains, the fears were that the robust lander craft would survive re-entry into earth’s atmosphere as it was originally engineered to withstand the harsh pressures and chemistry of Venus.

How and why then would sketches be emerging of Chinese plans to launch a sample-return mission to Venus in the next decade? Science Journalist Andrew Jones describes some of the challenges they will face collecting droplets of the highly acidic atmosphere somewhere 60km above the surface and turning round to head back to earth.

Why? William Bains of Cardiff University is one of a growing number of scientists interested in exploring some of the more exotic possibilities for complex organic biology in the otherwise destructive sulphuric, hot, dense, low pH clouds they will find. Could a different sort of information-encoding molecular chemistry enable life, though not as we know it?

Presenter: Roland Pease Producer: Alex Mansfield Production Coordinator: Jasmine Cerys George and Josie Hardy

Photo: A domestic dog receives a rabies vaccine during a mass vaccination in Bunda, Tanzania, October 8, 2012. (Chris Sweda/Chicago Tribune/Tribune News Service via Getty Images)


38min 45sec


Researching pain, painlessly

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