Sars CoV-2 has been with us for five years. In the first of a two-part special, Science in Action asks how well was science prepared for it? And are we any better prepared for the next one?Presenter: Roland Pease
Producer: Alex Mansfield, with Debbie Kilbride
Production co-ordinator: Jana Bennett-Holesworth

Five years of Covid: Part one

The BBC brings you all the week's science news.

As anti-science leaves research reeling, does evidence-based policy in a scientific society have much of a future? Michael Mann, Naomi Oreskes, Angie Rasmussen and Deb Houry discuss some of the sources and motivations that perhaps belie the current state of scientific affairs. Presenter: Roland Pease 
Producer: Alex Mansfield 
Production Coordinator: Jana Bennett-Holesworth (Image: The End street sign. Credit: Sanfel via Getty Images).

How science got here, and where next

As two species of coral are killed off by the 2023 heatwave in the Florida reefs, the abilities of different plankton species to cope with rising CO2 remain crucially unknown. Also, retrospective research shows a strong suggestion that mRNA covid vaccination might serendipitously boost certain types of cancer immunotherapy. And, if you can’t identify changing agricultural crop types from satellite observations, why not just strap a camera to your bike helmet? Presenter: Roland Pease 
Producer: Alex Mansfield 
Production co-ordinator: Jana Bennett-Holesworth (Photo: Dead elkhorn coral (Acropora palmata). Credit: Rolf von Riedmatten/Getty Images)

Coral extinctions and chalky unknowns

Ten years on from the Paris climate agreement, has it helped? Also, an international drought experiment, insights from 2D water, and social distancin in ants.
 
 
Presenter: Roland Pease
Producer: Alex Mansfield
Production co-ordinator: Jana Bennett-Holesworth(Photo: Small bushfire. Credit: Lea Scaddan/Getty Images)

Paris agreement impacts and drought realities

The 2025 Nobel prizes are announced this week – how did Science in Action’s predictions fare? Science author and thinker Philip Ball judges.The Whitley Fund for Nature this week hosted a “People for Planet” summit, exploring possible solutions to save nature. Amongst the speakers was Prof Martin Wikelski, of ICARUS, who has spent many years tracking wildlife around the world using tiny radio sensors. As he describes to Roland, he shortly hopes to launch a network of satellites to enable a global system to help us learn how hundreds of species are faring.Also, a new “Human Disease Blood Atlas” gets a boost, as described by Mathias Uhlén of SciLifeLab. Could an annual blood sample become a standard primary healthcare routine, mapping key proteins and their concentrations to provide early warning of hundreds of diseases?Meanwhile Nozair Khawaja of Free University of Berlin has been revisiting data from the Cassini mission to Enceladus, one of Saturn’s moons, back in 2008. His new analysis increases the prospects of habitable conditions deep on the ocean floor beneath the icy crust.Presenter: Roland Pease
Producer: Alex Mansfield
Production Coordinator: Jana Bennet-Holesworth(Image: Chair of the Nobel Committee for Chemistry explains a model during a press conference. Credit: Jonathan Nackstrand via Getty Images).

Old faces and big spaces in small places

Scientists detect for the first time an unknown source of GPS interference coming from space. Also, as AI begins to design more and more DNA sequences being manufactured synthetically, how can those manufacturers be sure that what their customers are asking for will not produce toxic proteins or lethal weapons? And… how camera traps in polish forests reveal that the big bad wolf is more scared of humans than anything else. For that last few years instances of deliberate jamming and interference of GNSS signals has become an expected feature of the wars the world is suffering. Yet this disruption of the signals that all of us use to navigate and tell the time nearly always emanate from devices on the ground, or maybe in the air. But in ongoing research reported recently by Todd Humphreys of University of Texas at Austin and colleagues around the world is beginning to reveal that since 2019 an intermittent yet powerful signal has been causing GPS failures across Europe and the North Atlantic. The episodes have been thankfully brief so far, but all the signs suggest it comes not from soldiers or aeroplanes, but from a distantly orbiting satellite somewhere over the Baltic Sea. It may not be malevolent, it could be a fault, but the net of suspicion is tightening. A team of scientists including some from Microsoft report today in a paper in the journal Science an investigation to try to strengthen the vetting of synthetic DNA requests around the world. As AI-designed sequencies increase in number and application, the factories that produce the bespoke DNA are in danger of making and supplying potentially dangerous sequences to customers with malicious intents. But how do you spot the bad proteins out of the almost infinite possible DNA recipes? Tessa Alexanian of the International Biosecurity and Biosafety Initiative for Science, and one of the authors explains some of the thinking. Finally, Liana Zanette of Western University in Ontario and colleagues have been hanging around in Polish forests scaring wolves. Why? Because as wolf numbers rise in protected reserves, more and more human-wolf interactions occur. And a suspicion has arisen that the legal protection they enjoy has led to them losing their fear of humans in a dangerous way. Not so, says Liana’s team, blowing away the straw arguments and setting fire to the political motivation to reduce their protection status. Wolves are still terrified of Nature’s apex predator – us. Presenter: Roland Pease 
Producer: Alex Mansfield 
Production Coordinator: Jana Bennett-Holesworth (Image: Simulation screen showing various flights for transportation and passengers. Credit: Oundum via Getty Images).

A mystery satellite has been jamming GPS in Europe

Epigenetic changes during early brain development, and the complexities of autism. Also, how bacteria learn to parry antibiotics, the subterranean burp that shook the Island of Santorini, and new guidance for sharing land between farming space and living space for the pollinators on which it depends. Presenter: Roland Pease 
Producer: Alex Mansfield 
Production Coordinator: Jana Bennett-Holesworth (Image: Blastocyst embryo, light micrograph. Credit: Science Photo Library via Getty Images).

Autism and the epigenetics of early brain development

Gravitational waves show two black holes merge just how Hawking predicted. Plus, a space mission without a target. And a Space probe without a confirmed budget.In January 2025 the LIGO gravitational wave observatories witnessed two distant black holes spinning into each other. In the ten years of LIGO’s operations, that’s not a first. But the instruments have been improved to such an extent that this time some very important predictions of General Relativity and out understanding of black holes could be tested. As Birmingham University’s Alberto Vecchio says, the elegant simplicity of the mathematics of black holes has passed a test, in particular Stephen Hawking’s prediction that the surface area of merging black holes can only be increased.Space craft have met comets before. But because spaceflight takes so long to plan and fund, we’ve only sent them to comets with human-lifetime orbital periods so far, because we know when they’re arriving. ESA wants to meet one we’ve never seen before, one that has never or seldom been in close to the sun, and never been barbecued and seared by the radiation. Colin Snodgrass of the University of Edinburgh explains the plan to launch and park a comet chaser in space to wait for one of these elusive extraterrestrial objects to come in from the cold.That, says Meg Schwamb of Queen’s University Belfast, is going to be much easier in the next few years as the Vera Rubin Telescope begins its ten year survey cataloguing anything in the sky that changes. The type of sky survey it will provide will identify, it is hoped, many candidate first-time comets for the small fleet of spacecraft to intercept.Having a spacecraft ready in position rather than having to launch a new one anytime you want to do some science is a good place to be, one would think.NASA’s Juno mission has been delivering science from Jupiter since its launch, and is still functioning and able to deliver more. Yet NASA funds are under considerable threat, and as Scott Bolton tells Roland, at the end of this month Juno could be left slowly spiralling into the gas giant, silently collecting data but with no budget to keep the science going.Presenter: Roland Pease	
Producer: Alex Mansfield
Production Coordinator: Jana Bennett-Holesworth

Stephen Hawking gets it right again

Scientists’ latest plans for welcoming interstellar visitor 3I/Atlas next month, and arranging a rendezvous with comet Apophis in 2029, as heard this week at the EPSC-DPS international planetary science joint meeting in Helsinki. Presenter: Roland Pease 
Producer: Ella Hubber, with Alex Mansfield 
Production coordinator: Jana Bennett-Holesworth Image: Artist's impression of an asteroid in space (Credit: European Space Agency/ESA Science Office)

Asteroids, comets and where to find them

Despite the relatively low magnitude, earthquakes in Afghanistan this week have left more than1000 dead. Afghan researcher Zakeria Shnizai from the University of Oxford unpicks some of the main causes of the country’s vulnerability to earthquakes. Also this week, we talk to the climate scientist who led a 400+ page rebuttal to the US Department of Energy’s report on climate change. We hear about research which has mapped the activity of over 600,000 neurons in 279 regions of the mouse brain to learn more about how decisions are made. And we get the latest updates on 3I/ATLAS, the latest interstellar comet streaking its way across our solar system, just before it disappears behind the sun. Presenter: Roland Pease 
Producer: Ella Hubber 
Production Coordinator: Jana Bennett-Holesworth(Image: Magnitude 6.0 earthquake strikes eastern Afghanistan. Credit: Anadolu via Getty Images).

Why is Afghanistan so vulnerable to earthquakes?

What can modern epidemiological methods tell us about French Revolutionary history? Also, the origins of horse riding, solar systems, and star dust itself. Presenter: Roland Pease 
Producer: Alex Mansfield 
Production Coordinator: Jana Bennett-Holesworth (Image: Storming of the Bastille Paris France 1789 illustration. Credit: Grafissimo via Getty Images).

How Fear Spreads

A desktop nuclear fusion reactor that uses electrochemistry to up the ante. Also, a global survey of human wildfire exposures finds Africa burning ahead, plus tiny swarming robots and record-breaking 2024 ice melts from glaciers on Svalbard. Presenter: Roland Pease 
Producer: Alex Mansfield 
Production co-ordinator: Jana Holesworth (Photo: The Thunderbird Reactor at the University of British Columbia (UBC). Credit: Berlinguette Group/UBC)

Not cold fusion all over again

US Health Secretary RFK Jr’s call to retract a study on childhood vaccines is resisted by the journal. Also antibiotics get designed by AI, and a new way for stars to die. A study focussing on Danish childhood vaccination data has attracted the US Secretary for Health’s anger, as RFK jr calls for the journal in which it was published, the Annals of Internal Medicine, to retract it. The Editor, Christine Laine, talk to Science in Action about the strengths and challenges of observational studies. The cuts to prestigious US federal science funded research continue, as last week it was announced that $500 million funding for future mRNA vaccines would be withdrawn. Barney Graham, one of the pioneers in the field and prominent during the Covid vaccines, argues that the research will still happen, though maybe not in the US, as mRNA has become a fundamental area of global research. Meanwhile, strides are being made in the field of synthetic biology as Jim Collins and colleagues at MIT and Harvard have used AI to design potentially viable antibiotics for two important drug-resistant superbugs. Previously, AI has been used to comb through libraries of known antibiotics. This study has gone a step further, and used generative AI to design new ones, that can then be synthesised using real chemicals. Though a long way from being prescribable drugs, the team think this could herald a new golden age of antibiotic development – something which has been lacking in recent decades. Finally, it seems astronomers may have discovered a new way for a star to die, sort of. Supernova 2023zkd was seen to explode back in 2023, found by a team looking for odd events. It didn’t seem quite like normal supernovae, in that it took a bit longer to die down. Then the team looked back, and noticed that it had also been getting slowly brighter for almost a year. At 730 million light years away, in a galaxy far, far away, it also seemed to have been stripped of all its hydrogen and even stranger yet, appeared to have exploded twice. As Ashley Villar of the Harvard Smithsonian Center for Astrophysics explains, the almost unique observation fits with a model of the huge star getting closer to a black hole, the gravity of which may have disrupted the star enough to cause it to explode. Presenter: Roland Pease 
Producer: Ella Hubber with Alex Mansfield 
Production Coordinator: Jana Bennett-Holesworth (Image: Child getting a vaccine. Credit: Luis Alvarez via Getty Images)

Vaccine study retraction request rejected

As the United States secretary of health and human services, Robert F Kennedy Jr., announces a $500 million cut to mRNA vaccine research in the United States, we hear a statement from the Nobel Prize winning biologist who made mRNA vaccines possible. A team of scientists from Northwestern University have uncovered the pathway believed to protect some people from allergic reactions (even when they are sensitive to an allergen) and have tested a drug which could protect the most severely allergic. 
 
Also this week, satellite data shows that large parts of the Earth are running dangerously low on ground water. And although people often believe scientific fraud is committed by a few bad actors, a new paper uncovers networks of journals, editors, and authors who are allegedly cooperating to publish fraudulent papers. Presenter: Roland Pease 
Producer: Ella Hubber and Alex Mansfield 
Assistant producer: Minnie Harrop 
Production co-ordinator: Jana Bennett-Holesworth
 
(Photo: Allergy testing. Credit: Peter Dazeley/Getty Images)

An end to allergic reactions?

After most of the population of the Pacific rim sought higher ground this week, we speak with the architect of the tsunami warning technology. Also how aging Killifish might help us probe our senior moments. This week, an M8.8 earthquake near Kamchatka in the western pacific led to tsunami evacuation alerts thousands of miles away. Seismologist Judith Hubbard was writing about the area in the days leading up to it, following a M7.4 event 9 days before, which we now know to categorize as a foreshock. As she says, it’s these subduction zones between tectonic plates that give out the most energy, produce the biggest quakes, leading to the worst tsunamis. 
 
The Tsunami alarms were based on modelling developed by Vasily Titov of NOAA’s Pacific Marine Environmental Laboratory in Seattle. Having studied these phenomena for many decades, he describes the fine balance between the potential accuracy of a prediction, and the practical actionable advice authorities need to give out to save as many lives as possible. Finally, how can a short-lived African freshwater fish help scientists studying senescence? Stanford’s Judith Frydman and colleagues publish this week a study in Science that finds Killifish’s brain cells’ ability to encode proteins degrades with age, in keeping with similar patterns of older human brains. Because Killifish have such brief life cycles, yet seem to follow the brain cycles of most vertebrates, they provide an ideal model species from which to find out more, as she explains. Presenter: Roland Pease 
Producer: Imaan Moin and Alex Mansfield 
Production Coordinator: Jana Holesworth(Image Credit: Vasily Titov PMEL/NOAA)

Getting ahead of tsunamis

Have we found Betelgeuse’s ‘Betelbuddy?’ An astronomical mystery seems to be solved as the long-predicted stellar companion to the bright star Betelgeuse has been detected by a team of researchers led by Steve Howell of the NASA Ames Research Center using the Gemini North telescope in Hawaii. Steve discusses this breakthrough alongside astronomer Andrea Dupree of the Harvard Smithsonian Center for Astrophysics, who has discussed the predictions of this star on previous Science in Action programmes. Malaria is a mosquito-borne disease caused by the parasite plasmodium that kills more than half a million people each year. George Dimopoulos of the Johns Hopkins Malaria Research Institute is using gene editing and gene drive technology to target the parasites as they develop in the guts of mosquito. Can this new method disrupt the malaria parasite life cycle safely and sustainably? Our gut microbiomes are linked to our brains, but how can the bacteria in our colon communicate with our nervous system? M. Maya Kaelberer of the University of Arizona explains this neurobiotic sense, suggesting that the microbes in our large intestine communicate with specialised sensory cells in the gut. These cells send signals up to our brain and regulate our appetite. So, who really decides when you're hungry? Is it you, or is it your microbiome? Presenter: Roland Pease 
Producer: Imaan Moin with Alex Mansfield 
Production Coordinator: Jana Bennet-Holesworth (Image: Betelgeuse and Its Stellar Companion in Orion. Credit: International Gemini Observatory/NOIRLab/NSF/AURA Image Processing: M. Zamani (NSF NOIRLab))

Discovering Betelgeuse’s Betelbuddy

Two black holes have collided and combined in the largest merger yet observed. Mark Hannam of Cardiff University and member of the study explains how the Interferometer Gravitational Wave Observatories (LIGO) detected this ‘violent’ event through spacetime.
 
The lifestyle of ancient humans had an impact on their risk for infectious diseases. Astrid Iversen of the University of Oxford explains how the shift away from being hunter-gatherers played a role in the origins of human pathogens. Nitrogen fixation, or the process of organic compounds accessing nitrogen from the atmosphere via microorganisms, plays a key role in climate modelling. But prior estimations have long been missing key data to make accurate analysis. Carla Reis Ely of Oak Ridge Institute for Science and Education shares the updated facts and figures on global nitrogen fixation. How intelligent is artificial intelligence? Can AI start discovering new scientific laws in the year? Keyon Vafa of Harvard University put several AI models to the test to see if they could discover Newton’s law of gravity and understand the world around us. 
 
Presenter: Roland Pease 
Producer: Imaan Moin 
Production Coordinator: Jana Bennet-Holesworth (Image: Black Hole, digital illustration. Credit: Aaron Horowitz via Getty Images)

Biggest black hole merger observed

The European Space Agency plans to use satellite gravity data to track weakening ocean circulation systems. Rory Bingham of the University of Bristol explains how these satellites can ‘weigh’ the Earth’s water and might help resolve whether we’re approaching the climate tipping point of a shutdown of ocean circulation in the Atlantic Ocean, something we've been following for a while. Scientists have been able to retrieve ancient proteins from fossilized tooth enamel in the Canadian High Arctic. Ryan Sinclair Paterson from the University of Copenhagen tells us how he can fill in the blanks of the molecular tree of life with these proteins from over 20 million years ago. A few weeks ago, we discussed evidence of an impact of a massive crater in north-western Australia from over 3 billion years ago. However, recent independent evidence from another team of geologists indicate that the size and age of this crater’s impact may not be what some had previously thought. Alec Brenner of Yale University talks us through his analysis of the geologic evidence. Finally, we rediscover a forgotten pioneer of fusion science. Mark Chadwick discusses the research done by then-graduate student Arthur Ruhlig that helped develop the hydrogen bomb and thermonuclear physics. [This audio has been corrected since original broadcast to amend a misattribution in the script. Our apologies.]Presenter: Roland Pease 
Producers: Imaan Moin with Alex Mansfield 
Production Coordinator: Jana Bennett-Holesworth (Image: Map of North Atlantic Ocean currents, with Gulf Stream and other currents. Credit: PeterHermesFurian Via Getty Images.)

Tracking ocean circulation systems

There's a surge in cases and deaths from H5N1 bird flu in Cambodia - we hear what's the driver and how concerned we should be. Erik Karlsson, Head of Virology at the Pasteur Institute in Phnom Penh and director of the WHO’s H5 Reference Laboratory has been watching the uptick.An interstellar interloper has been spotted entering our solar system. Most likely a comet, and possibly visible in the sky, it’s just the third such visitor we’ve ever seen. Josep Trigo of Spain’s Institute of Space Sciences (CSIC) and the Catalan Institute for Space Studies is one of many astronomers keeping his eye out.DNA from an ancient Egyptian buried in cave 2,500 BCE, the oldest to date, tell a tale of travelling ancestors, according to research led by Adeline Morez of Liverpool John Moore’s University and published in Nature.Also, Corey Allard of Harvard university has been looking at a particular type of sea slug. Published in the journal Cell, the work has been trying to work out how these slugs effectively nurture and manage stolen chloroplasts – stolen from ingested plant cells - within their own bodies. Artfully, they may use these “Kleptoplasts” to dodge periods of food shortage. Presenter: Roland Pease
Producer: Alex Mansfield
Production Coordinator: Jazz GeorgePhoto Credit: Institut Pasteur du Cambodge

Bird flu surges in Cambodia

A spectacular new 10-year telescopic survey of the universe gets underway in Chile. Also, a project to create human chromosomes completely synthetically.Almost three decades ago Tony Tyson (now of UC Davis) and colleagues were standing in the control room of the world’s biggest (at the time) digital astronomical camera. It was 3am when he suggested astronomers could do better. This week, the Vera C Rubin Observatory unveiled first images from the telescope he envisioned. Unprecedented in so many ways, expect many discoveries to come from this unique machine.Another ambitious project known as SynHG kicks off this week, on the 25th anniversary of the publication of the first draft of the human genome, with a plan to develop the technology to potentially create a whole synthetic version. Jason Chin of MRC Laboratory of Molecular Laboratory in Cambridge and colleagues will be extending their previous work in synthetic biology to human DNA, whilst Joy Zheng of the University of Kent will be running a parallel project examining the ethical side of the objectives, and possibilities.Presenter: Roland Pease
Producer: Alex Mansfield
Production co-ordinator: Jazz GeorgePhoto Credit: NSF–DOE Vera C. Rubin Observatory

Vera C. Rubin Observatory first images

The universe is thought to consist of 70% Dark Energy, 25% Dark Matter, and just 5% Baryonic matter which is the atoms that make up you and me. At least, that’s what the models suggest. But a well-kept secret between astronomers and cosmologists for all these years has been that they have not actually ever seen almost half of that 5% normal matter because it is thinly dispersed as gas between the galaxies and galactic clusters. This week, two studies have been published putting that right.Satisfactory model-match #1:
Liam Connor of Harvard University with colleagues from Caltech have been using a mysterious phenomenon called Fast Radio Bursts (FBRs) to infer what the intergalactic medium is in between, and how much of it there is. Satisfactory model-match #2:
Konstanios Migkas of Leiden University and colleagues have been looking at the very faint x-ray signal from the intergalactic medium, removing the incidental x-ray sources such as black holes, and have managed to identify some structure - in this case a mind-bendingly huge filament of ionised gas stretching between two galactic superclusters - confirming the state of “Warm Hot Intergalactic Medium” (WHIM) as predicted for much of the universe.Of course, there is not just the cosmological standard model (lambdaCDM) that these satisfy in science today. There is also the remarkably resilient Standard Model of particle physics. A report this week from the US National Academies recommends the US begins building the world’s next particle collider to follow the work of the LHC (and FCC) at Cern. It should, as University of Tennessee at Knoxville’s Tova Holmes tells us, collide not ordinary, stable, easy to manipulate particles like protons and electrons, but muons. Finally, Shana Goffredi of Occidental College in California, has found a VERY odd spider. Diving to depths in the submersible Alvin, they have found that a species of small sea-spiders, Sericosura, actually farm bacteria on their exoskeleton. Why? Because they hang around methane seeps on the ocean floor, where a specialist bacteria can metabolize methane – something the spiders themselves can’t do. Not only do the spiders then graze on the bacteria they carry around, they even pass samples of the bacteria onto their offspring by leaving bacterial lunch-boxes in their egg-sacs.Presenter: Roland Pease
Producer: Alex Mansfield, with Sophie Ormiston
Production co-ordinator: Jasmine Cerys George(Photo Credit: Jack Madden, IllustrisTNG, Ralf Konietzka, Liam Connor/CfA)

Half a universe once lost now found

ESA’s Solar Orbiter camera probe begins raising its orbit towards the sun’s poles, whilst Betelgeuse’s elusive buddy continues to sneak past our best telescopes.Earlier this year, Solar Orbiter started to stretch its orbit over greater latitudes – effectively standing on cosmic tiptoes to catch a glimpse of the Sun’s poles. This week, we have seen the first ever pictures of them, and as solar scientist Steph Yardley tells us, the views will only get better.Meanwhile, Andrea Dupree of the Harvard Smithsonian Center for Astrophysics and colleagues have had time to study new Hubble and Chandra telescope observations of the iconic star Betelgeuse searching for signs of its hypothesised binary companion – dubbed “Betelbuddy”. The papers that appeared on the Arxiv pre-print server have not yet been fully peer-reviewed, but it seems astronomers will have to keep looking.Humans use machines to read gene sequences as best they can, but it takes time and is not perfect because we do not know what all of it means. Of course nature has its own genome reader – the ribosome. It is this that interprets the genetic instructions contained in our DNA and translates them into actual proteins. Viruses, of course, use it too when a cell gets infected. Shira Weingarten-Gabbay has this week demonstrated how scientists can make use of ribosomes too. Working somewhat in reverse, her team have identified many thousands of proteins previously unknown, that could for example provide targets for future vaccines or antivirals should the need arise.Finally, Nanshu Lu and team in the University of Texas at Austin have been working for some years on two-dimensional wearable electronic “E-Tattoos” to monitor health non-invasively through our skin. Their latest work, describes “A wireless forehead e-tattoo for mental workload estimation”.Presenter: Roland Pease
Producer: Alex Mansfield
Production co-ordinator: Jasmine Cerys GeorgePhoto Credit: ESA &#38; NASA/Solar Orbiter/SPICE Team, M. Janvier (ESA) &#38; J. Plowman (SwRI)

The first solar polar pictures

What is Fusarium graminearum and why were scientists allegedly smuggling it into the US? Also, Alpine Glacier collapse and an HIV capitulation.The FBI has accused two Chinese scientists of trying to smuggle a dangerous crop fungus into the US, calling it a potential agro-terrorist threat. But the fungus has long been widespread across US farms, and elsewhere, and is treatable. So what’s going on? Frédéric Suffert, Senior researcher in plant disease epidemiology at France’s National Research Institute for Agriculture, Food and Environment, gives us some insight.Last week, a glacier above the swiss village of Blatten collapsed and up to 12 million tonnes of ice and rock buried the idyllic, yet thankfully all-but evacuated, hamlet below. Daniel Farinotti of the Swiss Federal Institute of Technology explains how it was monitored more than any such event before, and maybe, despite the tragedy, could help inform the science of such events in a warming world.Amongst the latest cuts to scientific funding by the US government, two consortia working at advanced stages of a potential HIV vaccine have been told their funding will not continue. Dennis Burton of Scripps Research describes finding out.The recipient of the Royal Society Faraday Prize 2024 gave his prize lecture last week. Titled Science Under Threat: The Politics of Institutionalised Disinformation, Salim Abdul Karim’s lecture is available on YouTube. Afterwards, he was kindly able to have a chat with Science in Action about his theme. Presenter: Roland Pease
Producer: Alex Mansfield
Production co-ordinator: Jasmine Cerys George(Photo: A hand holding an ear of wheat. Credit: Heather Schlitz/Reuters)

Potential fungal 'Agroterror'?

China is aiming to join the small club of nations who have successfully returned scientific samples of asteroids for analysis on earth, teaching us more about how our and potentially other solar systems formed. Tianwen-2 launched successfully this week, bound for an asteroid known as Kamo‘oalewa, which sits in a very strange orbit of both the earth and the sun, making it a “quasi-satellite”. Last year, scientists including Patrick Michel of the Côte d'Azur Observatory in France, published an intriguing suggestion that Kamo‘oalewa might in fact not be a conventional asteroid, but instead be a small piece of our moon that was ejected when the Giordano Bruno crater formed. In a little over a year from now, we might find out if that is right.Do you have to hold text at arm’s length to read properly? Qiang Zhang, professor of physics at the University of Science and Technology of China, whose team recently published their demonstration of using a technique from radio astronomy but using optical light. Active Optical Interferometry involves using laser beams to achieve resolutions at distances far in excess of conventional imaging with lenses. As his team showed, and as Miles Paggett of Glasgow University admires, they managed to read newsprint sized letters at a distance of over 1.3km.Finally, how did the Inca Empire write things down, and who did the writing? It has been thought that ornate threads of strings and baubles known as khipu are how records were made for business and administration, probably by a decimal code of knots in strings. But the exact purpose, nature and any meaning encoded therein, has eluded scholars for decades. Sabine Hyland, an anthropologist at the University of St Andrews, Scotland, has been studying them for years, and recently was granted access to the records of a village, only the fourth known, to have continued a form of the khipu tradition after the Spanish conquest to this day. She believes that they could even provide us in the modern world with valuable climate data. Presenter: Roland Pease
Producer: Alex Mansfield
Production co-ordinator: Jazz George(A Long March-3B Y110 carrier rocket carrying China's Tianwen-2 probe blasts off from the Xichang Satellite Launch Center on 29 May, 2025 in Sichuan Province of China. Credit: VCG/Getty Images)

Thirteen months to a chip off the moon

This week, 124 countries agreed at the World Health Assembly in Geneva on measures aimed at preventing a future pandemic. The agreement very strongly favours a “One Health” approach, appreciating how so many potential pathogens originate in human-animal interactions. Still to agree on the terms of how to share pathogens and information with global science and vaccine researchers, eventually the treaty will need to be signed by at least 60 countries. But can the inequity between countries of the global south and north, and issues of intellectual property, be bridged?A new study on origins of the Nigerian mpox epidemic points strongly to zoonotic crossovers and mobility of wildlife in West Africa. Edyth Parker of Redeemer’s University in Nigeria describes their phylogenetic tree.Can the bovine form of H5N1 flu infect pigs, and could domestic pig populations then provide a crucible for further variants to develop? Jürgen Richt of Kansas State University and colleagues have been investigating. We need to keep up vigilance.Lucy van Dorp of University College London, working with a consortium including London’s Crick Institute, has been looking at a moment in the past when human activity provided an opportunity for a bacterial human pathogen to change its lifestyle. According to their phylogenetic tree, the bacterium Borrelia recurrentis (which causes louse-borne relapsing fever in humans) adapted and moved from ticks to human body lice around about the same time as humans started using woollen clothing.And Susan Lieberman, VP for International Policy at the Wildlife Conservation Society, was in the trenches of the Pandemic Agreement negotiations, and shares some of her hopes for its success. Image: World Health Assembly formally adopts by consensus world's first Pandemic Agreement, Geneva, Switzerland - 20 May 2025
Image Credit: Magali Girardin via EPA-EFE/ShutterstockPresenter: Roland Pease
Producer: Alex Mansfield

WHO Pandemic Agreement reached

In 2015, the World Health Organisation set the goal of eradicating rabies deaths from dog-bites to “Zero by 2030”. A team at the University of Glasgow and colleagues in Tanzania have been assessing the efficacy of dog vaccination schemes for reducing the numbers of human infections over the last 20 years. As Prof Katie Hampson tells Science in Action, in rural areas especially, vaccinating dog populations does work, but you need to keep at it, and not leave patches untouched. It should be funded as a public health measure, rather than a veterinary issue. Last weekend, the remains of a failed 1972 Soviet mission to Venus landed harmlessly somewhere back on earth. As the BBC’s Maddie Molloy explains, the fears were that the robust lander craft would survive re-entry into earth’s atmosphere as it was originally engineered to withstand the harsh pressures and chemistry of Venus. How and why then would sketches be emerging of Chinese plans to launch a sample-return mission to Venus in the next decade? Science Journalist Andrew Jones describes some of the challenges they will face collecting droplets of the highly acidic atmosphere somewhere 60km above the surface and turning round to head back to earth. 
Why? William Bains of Cardiff University is one of a growing number of scientists interested in exploring some of the more exotic possibilities for complex organic biology in the otherwise destructive sulphuric, hot, dense, low pH clouds they will find. Could a different sort of information-encoding molecular chemistry enable life, though not as we know it? Presenter: Roland Pease 
Producer: Alex Mansfield
Production Coordinator: Jasmine Cerys George and Josie Hardy Photo: A domestic dog receives a rabies vaccine during a mass vaccination in Bunda, Tanzania, October 8, 2012. (Chris Sweda/Chicago Tribune/Tribune News Service via Getty Images)

Vaccinating rabies’ reservoir dogs

This week, the White House posted an executive order which details the administration’s intent to stop ‘dangerous gain-of-function research’. We talk to Gigi Gronvall, an immunologist and biosecurity expert at Johns Hopkins University who fears the timing and added bureaucracy could stop all sorts of important biosciences unnecessarily, and that the order is somewhat ideologically driven.Also, Nasa’s Juno mission has provided data on the most powerful volcanic event ever recorded, which took place on the planet Io, one of Jupiter’s moons. Hellish Io, squeezed as it is by the immense gravity of Jupiter, has not been observed from its poles before in this manner. Last week at EGU25, Science in Action got to speak with the mission’s principal investigator, Scott Bolton of Southwest Research Institute.Still on Jupiter’s moons, we also ask whether there could there be life on Ganymede, Callisto, and Europa? Scientists believe their glaciated oceans may harbour conditions suitable for life. Also at the EGU meeting were Jonathan Lunine, chief scientist at Nasa’s Jet Propulsion Lab, and Athena Coustenis, director of research at the Paris Observatory in Meudon.Presenter: Roland Pease
Producer: Alex Mansfield with Tabby Taylor-Buck
Production co-ordinator: Josie Hardy(Photo: Clinical support technician extracts viruses from swab samples. Credit: Jane Barlow/Getty Images)

Gain-of-Function: Loss-of-Funding

Scientists from around the world have gathered together at the annual European Geosciences Union general assembly, to discuss current projects, working hypotheses and potential findings. There are nearly 18,000 in attendance this year and there is much to learn. AMOC – the Atlantic Meridional Overturning Circulation - brings warmth to the north and cooler waters to the south in huge volumes. Climate modellers have expressed concern for its collapse (and subsequent weather chaos) as temperatures rise more generally, but others have said it is more resilient. But Stefan Rhamstorf has announced that extending the models past 2100 can show a different picture. The odds have shifted from 10% to more like 50/50 if the Paris climate target is missed. Has such climate change ever occurred before? And if so, what drove it? Hana Jurikova and colleagues have been using novel techniques to detect a link between atmospheric CO2 levels and rapid climate change in the geological past, and explains how boron records in ancient brachiopods might give us a clue.What of the 6.2 magnitude earthquake near Istanbul last week? Could it have been worse? Will the next one be the big one? Expert Patricia Martínez-Garzón of GFZ in Germany doesn’t quite allay the fears.Could more lives be saved from landslides and flash floods if we could set up a warning system? Stefania Ursica hopes so, and has looked to animal behaviour to design a programme to scan networks of seismic monitoring stations’ output for the faint signals. Encoding different hunting and communication strategies – from nomadic whales to humming birds and bats, her new algorithm might be just the thing, though prediction will always be a different problem.Presenter: Roland Pease
Producer: Alex Mansfield with Sophie Ormiston
Production co-ordinator: Josie Hardy(Image: 3D render of a Topographic Map of Western Europe with the clouds from 27 January, 2025. Credit: Frank Ramspott/Getty Images)

Scientists of the world unite

Last week, the website covid.gov looked very different, containing information on coping with covid and US research. This week it leads you to a White House webpage outlining the lab-leak hypothesis – that the pandemic was the result of dodgy lab work at the Wuhan Institute of Virology. The scientific consensus however continues to suggest a zoonotic crossover event. And a preprint recently published by Zach Hensel of ITQB NOVA (NOVA University Lisbon) and Florence Débarre of the Sorbonne, adds new early sequences to the evidence base. As they suggest, it doesn’t seal the debate, but it certainly doesn’t surprise the scientists.As the Trump administration continues to rattle swords with US science, we speak with Lisa Fazio of Vanderbuilt University who found out abruptly her funding from the National Science Foundation is ending, and Don Ingber, founding director of Harvard University’s Wyss Institute about the impacts they are feeling from the federal belt tightening.Finally we learn this week of an eerie species of Hawai’ian caterpillar moth. Not only is it carnivorous, but it ties small pieces of the indigestible remains of insects and bugs found in spider webs to its case, like a gruesome, camouflaged suit of armour. Why? As Dan Rubinoff of Hawai’i describes, it protects it from the hungry host spider, making it appear as the leftovers of yesterday’s dinner, or perhaps the shed exoskeleton of the spider itself.Presenter: Roland Pease 
Producer: Alex Mansfield
Production Coordinator: Josie Hardy(Image: The view of Huanan seafood market on February 9, 2021 in Wuhan, Hubei Province, China. Credit: Getty Images)

Wet market SARS CoV-2 origins revisited

After 60 years of doubling computer complexity every two years, can Moore’s law still predict the future power of the devices we use?In 1965, electronics pioneer Gordon Moore was asked to predict the next ten years of progress with the then new-fangled silicon integrated circuits. He estimated, based on physics and manufacturing technologies then available what seemed remarkable: that every two years they would double in complexity, and halve in price, until 1975.60 years on, perhaps the even more remarkable thing is that they just kept doubling.Can Moore’s law hold into future decades? What are the next technological innovations that might keep it running? Sri Samavedam is the vice president for silicon technologies at imec in Belgium, whose job it is to think about the practicalities of manufacturing the next generations of chips years before they become real.Scott Aaronsen of the University of Texas is a thinker in the field of Quantum Computing – could quantum computing keep the rate of growth going? Or does it need to be thought of differently?One of the limitations on chip miniaturisation is the dissipation of heat from conventional electronic flow. Nick Harris of Lightmatter is looking at using photons rather than electrons to carry info and logic around a circuit with lower power losses.Stan Williams has spent much of his career thinking about new devices that could be fabricated into integrated circuits to give it all a push forward. And he tells Roland how the memristor could effectively bring the power of analogue computing to bear as we reach some of the limits of the digital age we have been living in.Presenter: Roland Pease
Producer: Alex Mansfield and Gareth Nelson-Davies

Any more for Moore’s Law?

Pain, particularly chronic pain, is hard to research. New therapeutics are hard to screen for. Patients are not all the same. Sergui Pascu and colleagues at Stanford university have been growing brain samples from stem cells. Then they began connecting different samples, specialised to represent different brain regions. This week they announce their most complex “assembloid” yet, one that even reacts to hot chilli, passing a signal from the sensory neurons through to the thinking bits. The hope is that it can provide insights on how pain, and potential painkillers, work.Human brains are notoriously large, particularly infants. Whilst for primates the human pelvis is quite narrow, to allow us to walk and run on two legs. This notoriously makes childbirth, well, not as straightforward as most other species. This evolutionary “obstetric dilemma” has been debated for decades. Marianne Brasil, of Western Washington University, and colleagues, have published this week a huge study of contemporary human genes and anatomies available from the UK Biobank to shed some more light on this ongoing compromise.Malta is an island in the Mediterranean no less than 80km from land. So how come Eleanor Scerri and colleagues have discovered archaeological evidence of hunter-gatherers living there from 8,500 years ago? And they didn’t just visit and leave. They stayed for perhaps a millennium before farming arrived. Maybe a rethink of what nautical capabilities our ancestors had in the deep past is needed? A year ago, Science in Action gate-crashed a conference looking at plans for meeting the forthcoming arrival of asteroid Apophis in 2029. This year the meeting is in Tokyo, and Richard Binzel, emeritus professor of Astronomy at MIT, gives us an update on how the space agencies are hoping to collaborate to maximise the scientific value from what will be a global, visible, phenomenon in just 4 years. Is there enough time to get our collective wits together?(Image: 3D illustration of Interconnected neurons with electrical pulses. Credit: Getty Images)Presenter: Roland Pease
Producer: Alex Mansfield
Production co-ordinator: Josie Hardy

Researching pain, painlessly

How Myanmar’s tragic earthquake left a 500km scar on the surface of the earth in just 90 seconds. Also, more hints of a link between shingles vaccines and reduced dementia, and how earth’s first oxygen breathers seem to have evolved way before there was enough oxygen to breath.Judith Hubbard is a seismologist and earthquake analyst who has been gleaning what scientific information we can find on the tragic quake that struck Myanmar last week. There seems to be some sort of link between the herpes virus that causes shingles and some people’s risk of Alzheimer’s dementia. At least, the latest paper appears to confirm so, according to an analysis published in Nature this week. Pascal Geldsetzer of Stanford University and colleagues have looked at data from public health records in NHS Wales in the UK, and have retrospectively performed a “natural experiment”, finding a clear suggestion that a vaccine against the virus that causes shingles seems to confer a lower likelihood of developing dementia over the subsequent seven years. Quite why this happens remains moot.And a long time ago, and for a long time, life on earth was nought but bacteria. The atmosphere was also nearly devoid of oxygen. These ancient bacteria leave scant fossil records, whilst the rocks show a clear time – known as the Great Oxidation Event – when earth’s atmosphere transformed to something more like the oxygen rich air we breath now. A pervading chicken-and-egg question asks whether the atmosphere changed and life adapted, or did life somehow evolve and transform the atmosphere? A team publishing in Science this week have performed an innovative analysis of bacterial genomes that suggests that the ability to use oxygen in respiration evolved some 900 million years before the atmosphere transformed. The question still stands, but as the team explain, the new analysis provides at least a clear timeline for why we breath the way we do today.Presenter: Roland Pease
Producer: Alex Mansfield
Production Coordinator: Josie Hardy(Image: People ride a scooter past the rubble of damaged Buddhist pagoda in Mandalay on April 3, 2025. Credit: Sai Aung MAIN / AFP via Getty Images)

Earthquakes and the first breath of life on Earth

This week, after five years of research, two newly discovered antiviral molecules have been shown to combat coronaviruses. Johan Neyts of the Rega Institute for Medical Research in Leuven outlines how he hopes the new molecule developed by his team might help us deal with emerging pandemics in the future. But as the US halts all Covid related research, will drugs like these ever hit the shelves? Among the grants terminated this week by the National Institute for Health is a programme called AViDD, AntiViral Drug Discovery, supporting 9 independent consortia. Annette von Delft of Oxford University and Ed Griffen of the drugs discovery company MedChemica spoke to us about the overnight shut down of years of work and importance of antiviral development. The longest ever carbon-based molecules have been discovered by the Mars Curiosity rover. Caroline Freissinet of the Laboratoire Atmosphères et Observations Spatiales talked us through the meticulous planning and geological chance that made this possible, and whether these long chain alkanes could be a clue to discovering life on mars. Researchers at Vanderbilt University have been delving into the genetic evolution of horses to discover the mutation that’s behind their runaway metabolic success. Gianni Castiglione explains how a mutation that should have been catastrophic instead helped horses to evolve from the size of dogs to the giant athletic animals we know today. Presenter: Roland Pease
Producer: Emily Bird
Production Coordinators: Jana Bennett-Holesworth and Josie Hardy(Photo: Two tablets of Roche Pharmaceuticals' Tamiflu. Photo by Nikos Pekiaridis/NurPhoto via Getty Images)

Breakthrough antivirals and fresh US grant cancellations

There is continued upheaval in US scientific institutions under the new Trump administration. This week $400 million dollars-worth of grants have been frozen at Columbia University in response to “illegal” protests on the campus. President Trump also recently accused the Biden Administration of spending $8 million dollars on "transgender mice" experiments. 
 
We talk to two scientists, Kelton Minor and Patricia Silveyra, who have been affected in different ways. Also, as the first data from the European Space Agency's Euclid mission is released, Euclid project leader Valeria Pettorino tells us how this impressive space telescope hopes to unlock the secrets of the dark universe.And, around this time last year we heard about the H5N1 strain of bird flu finally jumping to the Antarctica Peninsula. Today, an expedition led by virologist Antonio Alcami confirms that the virus has spread to every animal species at each site they visited.Presenter: Roland Pease
Producer: Ella Hubber
Production co-ordinator: Jana Holesworth and Josie Hardy(Photo: University of Minnesota researchers, scientists and other supporters protest against President Donald Trump's proposed scientific research funding cuts. Credit: Michael Siluk/Getty Images)

Columbia cuts and "transgender mice"

Five years after the WHO pandemic announcement, an H5N1 call to arms from global health leaders. Also, the oldest western European face is found, the oldest impact crater possibly identified, and strange radio signals from space maybe explained.Presenter: Roland Pease
Producer: Alex Mansfield
Production Coordinator: Jana Bennett-Holesworth(Image: US To Boost Egg Imports As Prices Soar On Bird Flu. Credit: Bloomberg via Getty).

New warnings, familiar faces, and radio pulses

As the new administration in the US continues to make cuts to government agencies and scientific funding, NOAA – the National Oceanic and Atmospheric Administration has been particularly trimmed. This week the professional organisation for weather forecasters – the American Meteorological Society has published a statement pleading for clemency, arguing that the whole US Weather Enterprise is at risk. It’s current president elect, veteran weather broadcaster Alan Sealls describes how it’s not just US weather forecasts that appear bleak.As the journal Science Advances publishes a special edition highlighting areas of women’s health research, we speak with two researchers who may have found a link between menopause – or perhaps hormonal changes – and the age it occurs, with Altzeimer’s Disease. Madeline Wood or the University of Toronto and Kaitlin Casaletto of UCSF describe how synaptic health – the fitness of the brain - at death seems even to be less attenuated in women who used hormonal therapy during their menopause. It is not however, yet suggested they are causally connected. But we do connect research vessel Polarstern to have an update from Autun Purser and Nottingham University’s molecular biologist Liz Chakrabarti on their nearly completed voyage to the Weddel Sea, in the challengingly chilly Antarctic. They are gathering data and surveying the fauna on the sea floor below what is mostly covered in 3-4 meters of ice. The Icefish they see there are some of the only vertebrates not to have haemoglobin – nor even red blood cells – in their blood. So how, we wonder, do they actually move oxygen around their bodies? Maybe when the team publish their findings – which they are racing to do - we’ll find out.Presenter: Roland Pease
Producer: Alex Mansfield
Production Coordinator: Jana Bennett-Holesworth(Image: National Hurricane Center Monitors Hurricane Beryl's Activity In The Caribbean. Credit: Joe Raedle/Getty Images)

An uncertain forecast for meteorology

Just two weeks ago the world learned of an asteroid that had an almost 3% chance of striking earth in less than a decade. Astronomers kept looking, and a team including Olivier Hainaut at ESO’s Very Large Telescope at Palanar, in Chile, have managed to narrow down the uncertainty such that we now know it will definitely not hit the earth. The secret of making such observations after most telescopes could no longer see it was down to the exceptionally dark skies there. But these may be under threat. A plan has been made to build a large power plant, including sustainable hydrogen production around 11km away from the otherwise isolated site, and astronomers around the world are rallying to call for the plant to be built further away so that its construction will not spoil the otherwise unique observation conditions. One of the signatories of a petition to that effect is Julia Siedel, also of ESO, who just last week published the first 3D atmospheric analysis of an exoplanet’s climate. As she explains, future similar observations using the forthcoming, co-sited Extremely Large Telescope could be thwarted before the telescope is even finished.Back on earth, the Atlantic Meridional Overturning Current (AMOC) continues to bring warmer air and nutrients north towards the Arctic, and colder, denser water south in the global ocean overturn. But are reports of its collapse under climate change justified? A new paper this week suggests that for the next century at least it is stable though it might slow down. Jonathan Baker of the UK Met office explains how the winds in the south mean the cycle will keep turning, though it may slow down.Talking of the Arctic, Yoel Fink of MIT has dressed a couple of royal marines in wearable computer fibres for their current icy patrol in the north of Canada. Far from going commando, their underwear is measuring temperature and calorific burn to help them avoid frostbite and the dangers of the extreme environment. Yoel’s paper this week describes the new device and the principle that in the future much of all of our healthcare will be provided by these sorts of wearable, stretchy, computing textiles monitoring our activities.Presenter: Roland Pease	
Producer: Alex Mansfield
Production co-ordinator: Jana Bennett-Holesworth and Josie Hardy(Photo: Celestial conjunction at Paranal. Credit: Y.Beletsky/ESO)

Asteroid 2024 YR4 crisis averted?

The Lancet this week features a paper calling for a financially sustainable network of influenza labs and experts across Europe. Marion Koopmans was one of the 32 expert signatures, and she describes how Europe needs to learn some lessons from the model developed previously in the US. The ongoing worries around avian H5N1 would be a great example of why funding for that sort of frontline strategic science needs not to be reliant on ad-hoc, potentially political, funding grants.This weekend, a conference is taking place in Asilomar, CA, to mark 50 years since the 1975 conference there at which scientists developed some rules and guidelines around the future practice of genetic science. The historic Asilomar conference is celebrated by many as the moment scientists first demonstrated that they could spot risks, and self-regulate their activities, around novel and disruptive technologies. Author and scientist Matthew Cobb of the University of Manchester, and Shobita Parthasarathy of the University of Michigan discuss how perhaps other perspectives on the Asilomar legacy should be considered.Presenter: Roland Pease
Producer: Alex Mansfield
Production Coordinator: Jana Bennett-Holesworth(Image: Herbert Boyer (UCSF) and Paul Berg (Stanford) at a conference at Asilomar, February 26, 1975. Credit: Peter Breining/San Francisco Chronicle via Getty Images)

Who runs science?

This week the recently spotted asteroid 2024 YR4 had its odds of missing us “spectacularly” slashed by 1 percentage point. Still nothing to worry about maintains Patrick Michel of the International Asteroid Warning Network, and he expects that with better tracking data in the next few months (even courtesy of the JWST) that tiny chance of collision will fall further. However, as he explains, it’s very comforting to know that we now have such a sophisticated tracking network, and even better, thanks to NASA’s DART mission, even a demonstrable method for doing something about it if the numbers go the other way…But other extraterrestrial bombardments are harder to detect at all. This week scientists of the KM3NeT collaboration report in the journal Nature their detection of the most energetic neutrino ever noticed. Almost countless numbers travel through the earth – and us – every second, but this little beauty arrived from deep space, plummeting through hundreds of miles of rock and sea (via Malta) to collide with a single molecule of water in the Mediterranean sea. As Paschal Coyle of Aix Marseille University happens to run a cubic kilometre of neutrino observatory in that area explains their huge instrument was barely begun when the record breaker smashed through the area in February 2023.Finally, years of breeding rice cultivars for higher yield may have subtly changed the plants relationship with the microbes in the paddies in which they grow, inadvertently boosting the amount of methane released into our atmosphere. New research, including 3 years of field trials in China have produced a new cultivar, breeding in some of the older stocks, with just as high yields yet up to 70 percent lower methane released. This could make a serious difference to global methane emissions, as Microbiologist Anna Schnürer of Uppsala BioCenter in Sweden describes.Presenter: Roland Pease
Producer: Alex Mansfield
Production Coordinator: Josie Hardy(Photo: Asteroid 2024 YR4 as observed by the Magdalena Ridge 2.4m telescope Credit: AFP/NASA/New Mexico Institute of Technology)

Hits from space

The mystery swarm of small earthquakes near the island of Santorini beg for more data collection. Also, the National Oceanic and Atmospheric Administration (NOAA) in the US goes offline and whales learn song like kids learn language.Presenter: Roland Pease
Producer: Alex Mansfield
Production co-ordinator: Josie Hardy(Photo: Greece earthquake. Credit: AFP)

Earthquakes swarms and whale chart toppers

Nasa's OSIRIS-REx mission to collect a sample from an asteroid has been a great success. Asteroid Bennu's sample yields a watery pool of history, thanks to an international team of scientists including the London Natural History Museum's Sarah Russell. Also, in a week of tumultuous changes to federal funding and programmes, we hear from some US scientists affected and concerned by Executive Orders from the White House. Betsy Southwood, formerly of the Environmental Protection Agency, is worried not just about the government employees’ careers, but the environment itself and the whole of environmental science in the US and the world. Chrystal Starbird runs a lab at the University of North Carolina and is worried about the fate of grants aimed at diversifying scientific expertise, but also that some grant schemes are getting erroneously included in the anti-DEI clampdown. And Lawrence Gostin is an eminent health lawyer, proud of the NIH and all it has achieved.Presenter: Roland Pease
Producer: Alex Mansfield
Production co-ordinator: Jana Bennett-Holesworth(Photo: OSIRIS-REx Sample Return. Credit: Nasa/Getty Images)

Make science great again

Thirty per cent of the Arctic is switching from carbon sink to carbon source. But could future fertilizer be made deep underground using less resources? Also, how and perhaps why globally 2024 had the highest number of fatal landslides in over 20 years, and an unexpected sound from space prompts a re-evaluation of how the earth’s magnetic field interacts with the environment around it.Presenter: Roland Pease
Producer: Alex Mansfield
Production co-ordinator: Jana Bennett-Holesworth(Photo: Magnificent icebergs. Credit: MB Photography/Getty Images)

Arctic carbon starting to flip

New types of snake-bite anti-venoms are designed by AI. Also, how much meat did human ancestors eat? How the Baltic Nord Stream gas pipeline rupture of 2022 was the biggest single release of methane ever caused by humans, and that Pluto met Charon, not with a bang, but more of a kiss.Using a high precision technique for spotting different isotopes of Nitrogen, Tina Lüdecke of the Max Planck Institute for Chemistry has concluded that a group of early hominin Australopithecus living in South Africa were predominantly vegetarian, putting the date that human ancestors started eating meat (and thence growing bigger brains) to more recently. The technique, she thinks, can enlighten prehistoric food webs and ecologies from millions of years ago.Last year’s Nobel prizes showed the potential new techniques of AI to design synthetic proteins. Timothy P Jenkins and colleagues decided to try designing treatments for snakebite venoms, with remarkable apparent success. It could save many thousands of lives a year.Since the September 2022 explosions at the Nord Stream gas pipeline in the Baltic sea, many different analyses of how much methane was released have provided a variety of estimates. This week, scientists at the UNEP International Methane emissions observatory – including Stephen Harris - published a study estimating it to be a little under half a million tonnes, making it by far the single biggest human caused release of this most dangerous greenhouse gas. Yet, they say, even that is a tiny fraction of what is released overall around the world every year. And Finally, a new analysis of the original formation of the Pluto-Charon binary Dwarf Planetary system suggests they – and possibly many other Kuiper belt pairing – were born of a gentle astronomical dance and a peck on the cheek, rather than the catastrophic collision we associate with the earth-moon’s fiery first date. And it may have lasted just a matter of days, according to author Adeene Denton of the University of Arizona.Presenter: Roland Pease
Producer: Alex Mansfield
Production Coordinator: Jana Bennett-Holesworth(Photo: Gorilla feeding. Credit: WLDavies/Getty Images)

AI antivenoms and vegetarian hominids

H5N1 bird flu is still spreading across farms in the USA and this week claimed its first human life in North America - an elderly patient in Louisiana infected by backyard poultry. But last week, Sonja Olsen, Associate Director for Preparedness and Response in the CDC’s flu division, and her colleague Shikha Garg, published new analysis in the New England Journal of Medicine summarizing the human cases and epidemiology so far. A lab study underscoring a suspected link between the virus responsible for cold sores, and Alzheimers, the most common form of dementia, has been published in Science Signalling this week. The study, by Dana Cairns of Tufts University, looks at whether repetitive brain trauma – another risk factor - adds to the evidence that latent herpes simplex can be involved. Song Lin, a chemist at Cornell University who has won prizes for pioneering the use of electrical currents to drive chemical reactions rather than heat, has teamed up with Cornell micro engineer Paul McEuen to power up a new kind of chemistry and invent another kind of SPECS – an acronym for Small Photoelectronics for Electrochemical Synthesis. They outlined their first generation device and the promises it brings in Nature this week.Presenter: Roland Pease
Producer: Alex Mansfield
Production co-ordinator: Jana Bennett-Holesworth(Photo: Chickens eating feed. Credit: San Francisco Chronicle/Getty Images)

First US avian flu fatality

Sars CoV-2 has been with us for five years. In the second of a 2-part special, Science in Action asks how well was science prepared for it? And are we any better prepared for the next one? Presenter: Roland Pease 
Producer: Alex Mansfield, with Debbie Kilbride 
Production Coordinator: Jana Bennett-Holesworth

Five years of Covid: Part two

New insights into how our skin learns to tolerate and co-exist with bacteria on its surface show great potential for the development of simpler and less invasive vaccines. Stanford University’s Djenet Bousbaine has published two papers in Nature detailing the microbiological research and mouse vaccination experiments that could change the future of immunisation.
 
The Sun is the hardest place in the Solar System to reach. But by the time the next edition of Science in Action is on air, NASA’s Parker Solar Probe will have swooped through the scorching corona layer of the Sun, re-emerged, and be readying itself to relay the details of magnetic fields and particle storms to the team. NASA Helioscience deputy manager, Nicky Rayl, reveals all about the mission and explains why the Parker Probe’s future looks bright.
 
And a trip half a billion years back - and then some - to the dawn of complex life here on Earth. Microfossil hunter Shuhai Xiao, from Virginia Polytechnic Institute and State University, has been compiling a single statistical database to better understand evolution during the so-called ‘boring billion’, why subsequent changes on the planet triggered a new diversity of species to emerge, and how the interplay between biology and geology has paved the way for modern life as we know it.Presenter: Roland Pease
Producer: Alex Mansfield
Assistant Producer: William Hornbrook
Production Coordinator: Jana Bennett-Holesworth(Image: Solar Activity Captured in H-Alpha Filter. Credit: Manuel Romano/NurPhoto via Getty Images.)

Sun Grazing

Heatwaves in the pacific ocean have had a devastating effect on seabird populations in the north eastern US. Julia Parrish and colleagues publish this week 4 million deaths of Alaskan common murres attributable to rising water temperatures during 2014-16, representing half the population. One idea is that the fish on which the birds feed swim at deeper depths to find cooler temperatures, taking them below the depth the birds can dive. Worse, the reduced population numbers have endured almost ten years later. Pre-eclampsia affects up to 5 percent of pregnancies across the world. It reduces blood flow through the placenta, endangering mother, and even hindering the development of the foetus. But a promising approach to a possible therapy is described by Kelsey Swingle and colleagues this week. Much like some covid vaccines, by using a sort of lipid nanoparticles to deliver mRNA directly to the placenta in pregnant mice has resulted in healthier outcomes by widening the placental capillaries, allowing blood to flow more normally.Angie Rasmussen updates Roland on some of the work reported at a conference in Japan this week, pointing more directly to the covid-19 pandemic originating from wild animals at the Wuhan market.And in two coordinated papers published in the journals Science and Nature this week, scientists have narrowed down the period of time in history that modern humans and neanderthals interbred, leading to nearly everyone outside of sub-Saharan Africa sharing up to 2% of European Neanderthal DNA today. The question remains as to whether it was a benefit or not to the resulting hybrid population. Co-author Manjusha Chintalapati and colleagues describe how not all the neanderthal crossovers went on to survive pre-history to count as our direct ancestors. But one period of time, around 47,000 years ago is stamped on (nearly) all of us.Presenter: Roland Pease
Producer: Alex Mansfield
Production Coordinator: Jana Bennett-Holesworth and Josie Hardy(Image: Group of common murres on a breeding colony in Alaska. Credit: Sarah Schoen/USGS)

Warming oceans kill millions of birds

Scientists have found that just one mutation in the current H5N1 virus in cattle can switch its preference from avian to human receptors. Jim Paulson and colleagues at the Scripps Institute did not use the whole virus to investigate this, but proteins from one of the Texas farm workers found to be infected. It suggests the bovine H5N1 virus has already evolved subtly. Meanwhile, Richard Webby of St. Jude Children's Research Hospital in Memphis helps us catch up on the latest known about the case of the Canadian teenager taken seriously ill a month ago with a different variant of avian H5N1.
 
A debate has been rumbling this last year about the extent of ocean warming by, perhaps paradoxically, the reduction of particulate pollution from the fuel used by ships. The idea is that the small particles of sulphates and nitrates in the soot from funnels actually formed clouds over shipping lanes out at sea. This in turn sheltered the oceans to some extent from solar radiation, thus making latter decades of the 20th century seem cooler than they would have measured today. Hence, removing the particulate pollution from bunker fuel, mandated by the International Maritime Organisation a few years ago, may have contributed to the surge in ocean temperatures witnessed in the last two years. Daniele Visione, of Cornell, and colleagues have done the modelling and found that there has indeed been a noticeable effect.
 
But earth’s oceans are certainly not as hot as Venus’ ones, if indeed such oceans ever existed. It has long been held that once upon a time our sunward neighbour might have possessed liquid water oceans, long since boiled off by runaway greenhouse effects of the atmosphere. But, breaking with science fiction visions of aliens paddling in temperate seas, Tereza Constantinou of Cambridge University has been looking at the gases coming out of the volcanos on Venus, and has concluded that the planet never had such surface water, basically because the rocks from which magma is made don’t billow steam when they boil today. 
 
Presented by Roland Pease
Produced by Alex Mansfield with Debbie Kilbride
Production Coordinator: Jana Bennett-Holesworth(Image: Bird Flu in Dairy Cows; Credit: The Washington Post via Getty Images)

Bovine H5N1 gets a sniff of humans

November 1974 became known as the “November Revolution” in particle physics. Two teams on either side of the US discovered the same particle - the “J/psi” meson. On the "J" team, at the Brookhaven National Laboratory, Sau Lan Wu and colleagues were smashing protons and neutrons together and looking for electrons and positron pairs in the debris. Over at Stanford on the other side of the US, Dr Michael Riordan was in a lab with the "psi" team who, in some ways the other direction, were smashing electrons and positrons together to see what was created. They both, unbeknownst to each other, found a peak around 3.1Gev.It was shortly after that the full significance was clear. The existence of this particle confirmed a new type of quark, theorised in what we now call the Standard Model, but never before observed - the Charm quark. And with Prof Sau Lan Wu’s team’s subsequent discovery of gluons – the things that hold it all together – a pattern appeared in what had been the chaos of high energy physics and the nature of matter. Sau Lan and Michael (author of "The Hunting of the Quark: A True Story of Modern Physics") tell Roland the story.Prof Matthew Genge and colleagues at the Natural History Museum in London have found evidence of a bacillus growing on samples of the asteroid Ryugu brought back from space by the Hayabusa 2 mission. Rather than evidence for alien life, as they suggest in a paper this month, the contamination shows how easily terrestrial microorganisms can colonise space rocks, even when subjected to the strictest control precautions.And Per Ahlberg of Uppsala University and colleagues report in Science how they have taken a load of fossilised faecal matter and mapped out the evolution of dinosaur diets. First came the carnivores… then the vegetarian revolution…(Photo: Samuel Ting (front) shown with members of his J/psi experimental team. Credit: Brookhaven National Laboratory)Presenter: Roland Pease 
Producer: Alex Mansfield

Fifty years of Charm

It is hard not to have noticed the intensity of storms around the world this year, not least the Atlantic storms that battered the eastern US. A new study, using a new technique, confirms their attribution to climate change, and goes further, finding that many of them were actually raised in intensity category compared to how strong they might have been in a world without anthropogenic climate change. The costs are already extraordinary, according to Daniel Gilford of Climate Central in Princeton.When it comes to wildlife conservation, one of the underestimated parameters is the “old and wise” individuals in a population. According to a review paper in the journal Science, not only are earth’s old animals in decline, in many species they are vital to recovery and resilience when outside factors endanger numbers. As co-author Lauren Brent of Exeter University points out, these sorts of nuance are not always looked out for in conservation estimates.Chimps have culture, but is their culture cumulative and transmissible or innate and intuitive? Comparing a large database of observed chimpanzee behaviours, together with genetic lineages, Cassandra Gunasekaram and Andrea Migliano, of the University of Zurich, found that types of more complex tool usage can be correlated with reproductive overlaps between different chimp communities. The wandering females maybe carry tech knowledge with them when they travel to find new mates. Is this something both chimps and humans inherited from a common ancestor?And finally, as the harvesting of deep ocean polymetallic nodules gets nearer to commercial reality, the French research ship L’Atalante sets sail this week to study the animals that live on and around these strange chemical balls scattered across the abyssal plains of the mid pacific ocean. As lead scientist aboard, Pierre-Antoine Dessandier tells us, it is essential to understand how these animals live in the dark, 5km down, before the habitats are disturbed. The Eden mission will be searching the Clarion-Clipperton zone until January 2025.Presenter: Roland Pease
Producer: Alex Mansfield with Eliane Glaser
Production co-ordinator: Jana Bennett-Holesworth(Photo: Hurricane Milton seen from the International Space Station. Credit: Nasa/Getty Images)

Faster, wetter, worse tropical storms

Before December, the United Nations aims to have a global treaty in place covering efforts to limit global plastic production and pollution. In a paper in the journal Science, a team of scientists have used machine learning to estimate what happens by 2050 if we do nothing. But they have also found that the problem is solvable, with the right political will, and as marine ecologist Neil Nathan of UCSB points out, with surprisingly little new rules, waste could be reduced by 91%.Machine learning this week has also helped in the creation of Evo, a tool that has created a sort of chat-GPT for the language of life, DNA. Patrick Hsu, of the University of California at Berkeley is very optimistic that the power of this tool both to predict function and one day even design whole organisms is a foundational new approach. Migratory birds navigate vast distances without GPS. It’s long been strongly suspected that they use the earth’s magnetic field to find their way, but Richard Holland of Bangor University and colleagues have found nuance in the way they do, and publish their findings in Proceedings of the Royal Society B this week. Using electromagnetic cages they have fooled individual warblers into acting as if they were in Russia, whilst actually still being in Austria.Meanwhile, Daniele Sorini, a cosmologist at Durham University has been thinking about dark energy and the possibility of our existence. In a thought experiment wondering what changing the density of dark energy would do to the likelihood of our being here to even think about it. Slightly contrary to what many reason is the fine-tuning of universal constants to allow us, as intelligent observers, to exist, Daniele and colleagues calculate that actually our observed density of dark energy is not the most likely to allow intelligent life. If there are other universes in the multiverse, most observers would think there was much more dark energy than we do. You can read up about it in the Monthly Notices of the Royal Astronomical Society, if you are an intelligent observer yourself.Presenter: Roland Pease
Producer: Alex Mansfield with Eliane Glaser
Production Coordinator: Jana Bennett-Holesworth (Image: Plastic waste issues in Philippines. Credit: Daniel Ceng/Anadolu via Getty Images)

Drastic plastic reductions

Many coronaviruses exist in nature that we don’t know much about. We don’t even know how and whether most of them might bind to human cells. Research published in Nature, by scientists at Wuhan and Washington Universities, describes a new way of designing novel receptor sites on cell cultures so that many types of coronavirus may now be cultured and studied to ascertain their risk to humans. Cambridge virologist Ravindra Gupta, who is not one of the authors, gives Science in Action his take on the risks versus the reward.Dotted around the remains of Pompeii, visitors are often struck by the plaster casts of some of the victims’ dying moments. During recent restoration of several of these casts, scientists were able to extract DNA samples from bones which had previously been enveloped by plaster since their initial discovery. As Alissa Mittnik of the Max Planck Institute for Evolutionary Anthropology describes, some of the findings confound our previous narratives about their lives, relationships, and even their genders.Rozenn Pineau, a plant evolutionary geneticist at the University of Chicago in Illinois, has been investigating the unique evolutionary history of the world's oldest (and biggest) tree - "Pando".And finally, the oldest known tadpole is described from a 160 million year old Argentinian fossil by biologist Mariana Chuliver.Presented by Roland Pease
Produced by Alex Mansfield, with Eliane Glaser
Production Coordination by Jana Bennett-Holesworth (Image: Illustration of Covid-19 coronavirus binding to human cell. Credit: Kateryna Kon via Getty Images)

New ways to study coronaviruses

This week at least 150 people have been killed due to devastating flash flooding sweeping through areas of Valencia in Spain. Ana Camarasa Belmonte, Professor of Physical Geography at the University of Valencia, has been studying the flood patterns and hydrology of the area for years. Even she was astounded by the magnitude of the inundation. And, as Jess Neumann of Reading University in the UK tells Roland, part of the tragedy is that the effective communication of risk somehow relies on citizens being able to adequately imagine the almost unimaginable.Ten years ago this week, Friederike Otto and colleagues founded the World Weather Attribution network. The network aims to provide quick analysis of climate change's impact on on extreme weather events. They have already found that the Spanish flooding was made more intense, and more likely, by our warming world. Earlier in the week they published a different analysis of the 10 most deadly, extreme-weather events of this century. They concluded that all 10 events were made more extreme or more likely by climate change, and that these 10 events alone account for some 570,000 deaths.In the US, Scientists have tested the strain of H5N1 bird flu swabbed from the eye of an infected Texan farm worker. They found it to be both lethal and transmissible via the respiratory tract of mice and ferrets. It contains a mutation PB2-627K, common in avian viruses in mammalian cells, as Amie Eisfeld of the Universoity of Wisconsin-Madison explains.Presented by Roland Pease
Produced by Alex Mansfield
Production Coordination by Jana Bennett-Holesworth(Image: Aftermath of catastrophic floods in Spain's Valencia. Credit: Anadolu via Getty Images)

Global warming strikes again

Betelgeuse, one of the brightest and most famous stars in the northern night sky, has varied in brightness with an elusive pattern ever since observations began. Many theories exist as to why it ebbs and flows with apparently two distinct rhythms – one shorter and another around 2000 days long.But just recently two independent astronomical teams have unveiled papers suggesting the existence of an orbital companion circling the red giant. About the size of our own sun, the “Betelbuddy” may whizz round Betelgeuse, almost skimming its surface, every 2000 days. And why haven’t we seen the Betelbuddy before? Because, from here, it would be a million times fainter than Betelgeuse itself, as one of the authors, and long-time Betelgeuse watcher, Andrea Dupree of Harvard and Smithsonian Centre for Astrophysics explains.Back here on earth, Omar Yaghi of Berkeley, University of California and colleagues have been designing a new material that can scrub carbon dioxide out of the air in minutes. They have patented this type of Covalent Organic Framework (COF) and are hoping to scale up production such that a few hundred tonnes deployed around our biggest cities could solve our CO2 crisis.But then what do you do with all those gigatonnes of CO2? Maybe one thing would be to use solar power to convert it into plant food. Robert Jinkerson and colleagues describe in the journal Joule a proposal to transform global food production into “Electro-Agriculture”, growing plants, fungi and algae on acetate made from solar energy. Their proposal would also shrink the global footprint of farming to allow more natural habitat.And finally, Michael Frachetti of Washington University in St Louis has published an archaeological survey of two lost conurbations in the mountains of southern Uzbekistan that he and colleagues rediscovered in the last few years. He argues that the scale and complexity of these dwelling, and their location over 2000m, way above normal agricultural altitude mean we need to reconsider these stops on what would have been the Silk Road, around 600-1000 CE, perhaps even pointing at a very early industrial economy.Presenter: Roland Pease
Producer: Alex Mansfield with Andrew Lewis(Image: Orion sink to Kashimayarigadake. Credit: Getty)

Betelbuddy and Silk Road Cities

The “dewilding” effects of fish farming and mariculture are in the spotlight this week. Farmed fish can impact marine ecosystems in several ways, and surprisingly one of those is the effect it has on consumer perceptions of the impact of eating farmed fish, as researchers Becca Franks of NYU and Laurie Sellars at Yale suggest. Meanwhile, Manu Prakesh and colleagues at Stanford University in the US have found a remarkable plankton that can traverse the depths of the oceans by ballooning to five times its size, giving clues as to how an important carbon sink actually works. And Monika Bright at the University of Vienna has found animals and tubeworms living in the very rock below volcanic hydrothermal vents. Life finds a way… …But not always. 445 million years ago the second worst mass extinction event wiped out countless species of life on earth. But why? This week astronomer Chrysa Avdellidou of Leicester University and colleagues say they have found the origin for a famous meteor event that also happened around that time. Presenter: Roland Pease 
Producer: Alex Mansfield
Production co-ordinator: Andrew Rhys Lewis(Image: Aerial view of seagulls following a fishing trawler. Credit: Felix Cesare via Getty Images)

Marvels of life and death

In the week the Nobel prizes for science are announced, Roland Pease takes a look at the stories behind the breakthroughs being recognized, and the themes that connect them. From the discovery of the tiny fragments of RNA that regulate our cells’ behaviour, via computer structures that resemble our brains, and harnessing those sorts of computers to design drugs and medicines, it has been one of the most interdisciplinary years for the prize panellists. We hear from old students, recent colleagues, laureates and lab (and life) partners, including Rosalind “Candy” Lee and her husband Victor Ambros, of UMass Chan Medical School, US, Erika DeBenedictus of the Crick Institute, UK, and Dmitri Krotov of IBM Research. Presented: Roland Pease 
Produced: Alex Mansfield
Production co-ordinator: Andrew Rhys Lewis(Photo: 3d rendering of RNA strands and lipid-based nanoparticles or liposome. Credit: Love Employee via Getty Images)

Nobel convergence

As we were putting the finishing touches to last week’s Science in Action, the US National Weather Service was warning of Hurricane Helene’s fast approach to the Florida coast – alerting people to ‘unsurvivable’ storm surges of up to 6 metres. But the category 4 storm powered, as forecast, far past the coast and into the rugged interior of Tennessee and the Carolinas. 150 billion tonnes of rainfall are estimated to have been dumped there, with devastating consequences for the towns and villages snuggled into the deep-cut valleys of the region. Bloomberg says the event could cost $160 billion. Extreme warmth in the Gulf of Mexico helped fuel the hurricane, and within a few days Berkeley climatologist Michael Wehner had computed the fingerprint of climate change on the event. The journal Nature published this week a study estimating the true number of casualties of hurricanes like Helene – not just those registered in the immediate aftermath, deaths caused by the instant trauma, but those in the months, even years, that follow, because of the disruption to lives and infrastructure. Rachel Young of Stanford University was herself surprised by the scale of harm her calculations revealed. At least the dams held in North Carolina during Helene, although the sight of torrents of water gushing down the protective spillways at the peak was fearsome to see. A year ago, the two dams upstream of the Libyan port Derna both failed during Storm Daniel – ripping out the heart of the city and claiming at least 6000 lives. We reported what we could at the time here on Science in Action. But a World Bank study on the disaster reported back to an international dam conference in India this week a more detailed investigation – though the fractious politics of Libya put constraints on their work. Climate change was a massive part – normal monthly September rain in the area is 1.5 mm – but over 200 mm, maybe 400, fell on the hills behind Derna the night of the 10th. But it was the report of independent engineer Ahmed Chraibi that interested Science in Action – on the condition of the two dams, one just on the edge of the city, the other larger one 15 km upstream. He confirmed these had been built, in the 70s, for flood protection not to store water, but were in a shocking state long before last year’s cataclysm. You’ve not been paying attention here in the past 5 years if you haven’t learned how clever our immune system is in recognising viruses that invade our bodies. Different arms of the system like antibodies and white blood cells can take on the viruses directly, or kill infected cells to stop the infection spreading further. But it’s slow to respond to new infections, which is why our pharmacies also stock antivirals, small molecules which also lock onto components of viruses to stop them replicating. Too often though, they’re not as effective as we’d like. Flu antivirals for example work only if you catch the infection very early. So I was intrigued to read in the Proceedings of the National Academy this week of a new kind of drug that is like an antiviral, but gets the immune system to do the hard work. Imrul Shahria reckoned there are all kinds of antibodies and immune cells floating through our tissues not doing much, but that could be tricked into tackling flu infections – with a little molecular deception. He's effectively hacked the flu antiviral zanamivir which locks onto the neuraminidase protein – the N – of flu viruses, and given it immune superpowers. Presenter: Roland Pease 
Producer: Alex Mansfield
Production co-ordinator: Andrew Rhys Lewis(Photo: Hurricane Helene causes massive flooding across swaths of western North Carolina. Credit: Melissa Sue Gerrits/Getty Images)

Excesses of rain

Valerie Trouet of the University of Arizona tells us how tree-ring data has been used to show how the jet stream has shaped extreme weather in Europe for centuries, influencing harvests, wildfires and epidemics. Monash University’s Andy Tomkins discusses how, around 460 million years ago, the Earth was briefly encircled by a ring of dust – like Saturn is today, and that the resulting temporary astronomical shade may have cooled the planet. Andy proposes that this dust came from an asteroid which had a close encounter with our planet. And the cell biology of choking on your drink with Laura Seeholzer from the University of California, San Francisco. Laura has won the 2024 Eppendorf &#38; Science Prize for Neurobiology recognising her work on the discovery of how neuroendocrine cells protect our airways.Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production co-ordinator: Andrew Rhys Lewis(Photo: Members of the research team collected tree ring samples at various locations in Europe, including the Balkan region. Credit: Courtesy of Valerie Trouet)

Historic weather extremes revealed using tree-rings

The Sahara Desert has been experiencing unusually heavy rainfall due to an extratropical cyclone, causing flash floods in Morocco. We hear from Moshe Armon of the Hebrew University of Jerusalem. A 485-million-year temperature record of Earth reveals Phanerozoic climate variability. Brian Huber of the Smithsonian National Museum of Natural History in Washington DC tells us more. And Mary Lewis of Reading University discusses new research looking into what puberty was like for our ancestors towards the end of the last ice age. Teenagers from 25,000 years ago went through similar puberty stages as modern-day adolescents. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production co-ordinator: Andrew Rhys Lewis (Photo: Moroccan municipal workers and members of Auxiliary Forces help drain a road in a flooded neighbourhood in the city of Ouarzazate. Credit: Abderahim Elbcir/AFP/Getty Images)

Flash floods in the Sahara

Nearly a year ago, the top of a mountain on the Greenland coast broke off and slid a thousand metres down into the Dickson Fjord. The impact created a tsunami that started two-hundred-metres-high and sloshed between the cliffs for nine days, producing a global seismic signal. But it was so remote, only now are the details becoming clear. We hear from Paula Koelemeijer, Wieter Boone and Søren Rysgaard. The decline of the ancient inhabitants of Rapa Nui was unlikely to have been caused by a self-inflicted population collapse, thereby rejecting a contentious theory of ‘ecological suicide’. Anna-Sapfo Malaspinas of the University of Lausanne discusses her team’s findings which shed light on the population history of the island formerly known as Easter Island - one of the most remote inhabited places in the world, around 3,700 km west of South America and over 1,900 km east of the closest inhabited island. A newly identified species of wasp that attacks and lays eggs inside an adult fly has been discovered by Logan Moore and colleagues from Mississippi State University. Around 200 species of parasitoid wasps that target the fruit fly have been discovered to date - they lay their eggs in living creatures - all of which have been shown to target their hosts during vulnerable stages, such as when larvae or pupae. Until now, no wasp that attacks and develops inside the adult stage of a fruit fly host has been described. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production Coordinator: Andrew Rhys Lewis (Image: Copernicus Sentinel Data (2023). Credit: European Space Agency)

A landslide-induced megatsunami in Greenland

A Chinese survey of diseased animals farmed for their fur – such as mink, foxes and raccoon dogs - has revealed high levels of concerning viruses, including coronaviruses and flu viruses, many of which appear to jump easily from species to species. John Pettersson of Uppsala University discusses the threat to us humans. We learnt early on in the Covid-19 pandemic how important the genetic details of the virus were in tracking the spread and spotting new variants. The vaccines were designed from gene sequences shared electronically long before any biological samples became available. Virologist Emma Hodcroft has teamed up with researchers around the world to develop a new virus database, Pathoplexus, to speed up the sharing of gene sequences. Mpox outbreaks are causing concerns in Central and West Africa - particularly in the Democratic Republic of the Congo. A smallpox vaccine has started arriving, giving some protection against mpox. But there’s good news this week in an experimental vaccine developed especially for mpox by Moderna – one of the companies that brought us the mRNA vaccines against Covid-19. Galit Alter, vice president of immunology research at Moderna, tells us animal tests show that it appears to be highly effective. And we discuss embryonic eavesdropping with Francisco Ruiz-Raya of Glasgow University. In the yellow-legged-gull, baby bird embryos that have chattier parents tend to come out chattier themselves – and likely receive better care because of their enhanced communication. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production co-ordinator: Andrew Rhys Lewis (Image: A mink in a mink farm in the hands of a man. Credit: Neznam/Getty Images)

Concerning viruses found in fur farmed animals

In 1977 astronomers recorded a brief and strange radio transmission that looked like it perhaps had even come from an alien civilization. It was named the Wow! signal – because that’s what astronomer Jerry Ehman wrote on the computer printout upon its discovery. But now a team including Abel Méndez of the University of Puerto Rico at Arecibo have come up with an astrophysical hypothesis. An oil tanker which was attacked by Yemen's Houthi rebels in the Red Sea last week is still on fire and may be leaking oil, the US Pentagon says. The talk now is of an agreement to salvage the tanker so a crisis may be avoided, but marine ecologist Carlos Duarte of the King Abdullah University of Science and Technology in Saudi Arabia explains how precious ecosystems are at risk. A meta-analysis of Mediterranean Sea marine species reveals the profound impact of the Messinian Salinity Crisis. Konstantina Agiadi of the University of Vienna tells us how this drastic environmental event resulted in the almost complete evaporation of the Mediterranean Sea roughly 5.5 million years ago and how the resulting changes still influence ecosystems today. Wildfires that swept across Canada last year are still burning in some parts. A new study has confirmed that they put into the atmosphere a vast amount of burned carbon, over half a billion tonnes. Only China, India and the USA emitted more fossil-fuel based carbon in that period. Brendan Byrne of NASA’s Jet Propulsion Laboratory has been using satellite-based observations to track the carbon release. Presenter: Roland Pease
Producer: Jonathan Blackwell
Production Coordinator: Andrew Rhys Lewis(Image: The Wow! signal represented as "6EQUJ5". Credit: NAAPO)

Wow! A mystery signal solved

Fishery assessment models – the “backbone” of fisheries management – overestimate the sustainability of the world’s fisheries, according to a study of 230 fisheries worldwide, and populations of many overfished species are in far worse condition than has been reported. We hear from Rainer Froese of GEOMAR - Helmholtz Centre for Ocean Research Kiel. The lunar south pole contains evidence of ancient magma ocean. An analysis of lunar soil in the Moon’s southern high-latitude regions, performed using data from India’s Chandrayaan-3 mission, suggests the presence of remnants of a former ocean of magma. Roland speaks to Santosh Vadawale of India’s Physical Research Laboratory. Stefanie Haustein of the School of Information Studies at Ottawa University discusses the article processing costs for open access of the journal publishing giants in science. The risk of a banana apocalypse could be near, but biologists, including Li-Jun Ma of the University of Massachusetts, might have found a key to their survival. Bananas are facing functional extinction due to the disease Fusarium wilt of banana caused by a fungal pathogen. Discovery of molecular mechanisms used by the banana-destroying microbe brings hope. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production Coordinator: Andrew Rhys Lewis(Image: Fisherman emptying net full of fish into hold on trawler. Credit: Monty Rakusen via Getty Images)

Fisheries mismanagement uncovered

In June this year there was the first detected occurrence of rabies in Cape fur seals, discovered after a rabies case in a dog that had been bitten by a seal. Professor Wanda Markotter, Director of the Centre for Viral Zoonoses at University of Pretoria, has been trying to work out how the virus spread into seals and how to keep people (and their pet dogs) safe. The Japan Meteorological Agency issued a seismic “advisory” last week alerting local authorities and the public to a heightened risk of a massive, tsunami-generating earthquake on its southeast coast. Californian emergency manager and sociologist James Goltz, has been working with Japanese experts to evaluate a new dynamic alert system that they introduced after the great 2011 earthquake and tsunami which claimed up to 20,000 lives further north. We hear from Professor Alan Jamieson from the depths of the Tonga Trench. He recently dived into it to see what weird and wonderful creatures he’d find there – but when he reached the bottom, he didn’t see what he expected...! And Steven Goderis of the Free University of Brussels tells us about the Chicxulub impactor - the massive asteroid smacked into Earth off the Mexican coast causing the mass extinction event which wiped out the dinosaurs. He’s part of a paper in the journal Science, looking into the history of the impactor - revealing it was a rare carbonaceous asteroid from beyond Jupiter. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production Coordinator: Andrew Rhys Lewis (Image: Fighting Seals. Credit: Edwin Remsberg via Getty Images)

The spread of rabies into Cape fur seals

Cases of bird flu in farm workers in the US may be going underreported, due to supposed poor surveillance and lack of testing. We hear from Amy Maxmen of KFF Health News who has been reporting on a study in Texas. We hear from Bradley Moore, Professor of Marine Chemical Biology at University of California, San Diego about marine algae using massive enzymes, dubbed PKZILLAs to biosynthesize fish-killing toxins. BBC Science Correspondent Jonathan Amos gives us the latest on the two American astronauts who blasted off on a test mission to the International Space Station on 5 June, expecting to be back home in a matter of days. But the pair are still there, floating high above the Earth two months later - stuck indefinitely - now facing the sudden prospect of missing the summer entirely and even spending Christmas and New Year in space. And sea lion camera crews are helping researchers explore previously unmapped ocean habitats in southern Australia. Nathan Angelakis of the University of Adelaide tells us about working with the animal camera operators and what we can learn from viewing their movements. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production co-ordinator: Jana Bennett-Holesworth (Image: Young Farmer and Cows on Dairy Farm. Credit: EyeJoy via Getty Images)

Detecting undetected bird flu cases

Nasa's Perseverance Rover has found a fascinating rock on Mars that may indicate it hosted microbial life billions of years ago. Abigail Allwood, exobiologist at Nasa’s Jet Propulsion Lab, is on the team scrutinising the new Martian data. And a couple of newly discovered, approximately 500 year old fossils from the ‘Cambrian explosion’ of complexity caught presenter Roland Pease’s eye this week. First Martin Smith from Durham University tells us about a tiny grub that is ancestor to worms, insects, spiders and crustaceans. Then Ma Xiaoya, who has positions at both Yunnan University in China and Exeter University in the UK, tells us about a spiny slug that was also discovered in a famous fossil site in China. And the first sightings of the landscapes on the underside of the ice shelves that fringe Antarctica. These float atop the ocean around the frozen continent but effectively hold back the glaciers and ice sheets on the vast landmass. Their physical condition therefore is pretty critical in this warming world, Anna Wåhlin of Gothenburg University tells us. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production co-ordinator: Jana Bennett-Holesworth (Photo: Nasa’s Perseverance Mars rover taking a selfie on Mars. Credit: Nasa/JPL-Caltech/MSSS)

Examining Nasa's new evidence for Martian life

The near extinction of vultures in India may be responsible for an additional half a million human deaths between 2000 and 2005. The widespread use of the painkiller diclofenac in herds of cattle, starting in 1994, led to a massive decline in vulture populations in India, as the drug is poisonous to them. We hear from environmental economist Anant Sudarshan of Warwick University. Cooking like a Neanderthal - Mariana Nabais of the Catalan Institute of Human Paleoecology and Social Evolution has been replicating ancient butchering methods to learn how Neanderthals ate birds. A faster test for sepsis – we hear from Sunghoon Kwon of Seoul National University about a new method for identifying the pathogens involved in sepsis cases. The test has the potential to reduce the turnaround times normally associated with developing treatments for infections and may improve patient outcomes. And it seems we may have inherited some conversational habits from chimps – or rather from whatever came before us and chimps 6 million years ago. Cat Hobaiter of the School of Psychology and Neuroscience of St Andrews University and her colleagues have found that like humans, wild chimps engage in snappy, turn-taking conversations. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production Coordinator: Jana Bennett-Holesworth(Image: World Wildlife Day - Gyps fulvus feeding on a buffalo carcass at Kaziranga National Park in Assam, India. Credit: Anuwar Hazarika/NurPhoto via Getty Images)

The human cost of the decline of nature’s carcass cleaners

There’s an update from asteroid expert Patrick Michel about the European Space Agency’s Rapid Apophis Mission for Space Safety. The ESA have received permission to begin preparatory work for the planetary defence mission which will rendezvous with the asteroid Apophis, that will be passing by the Earth on Friday, April 13th 2029. And in news from the Moon this week – a massive cave has been discovered on its surface that might be a window into the body’s sub-surface, and even a ready-made lunar base for future astronauts to use. The claim was made in Nature Astronomy by a team of Italian planetary scientists, and two experts in remote sensing who have been re-interpreting radar data from a NASA orbiter - Leonardo Carrer and Lorenzo Bruzzone from University of Trento in Italy. 
 
In the magazine Science, there’s a call for a re-doubling of efforts to tackle malaria in Africa as signs grow that a leading treatment, Artemisinin, is becoming less effective. Deus Ishengoma, a malaria expert with the Tanzanian National Institute for Medical Research, is worried, having seen the transformation Artemesinin made in the past. Tiny solar-powered flying robots - an ultra-lightweight, solar-powered micro aerial vehicle capable of sustained flight is described in a paper published in Nature. Peng Jinzhe of the School of Energy and Power Engineering at Beihang University was part of the team behind the 8 millimetre robot. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production Coordinator: Jana Bennett-Holesworth (Image: ESA’s Ramses mission to asteroid Apophis. Credit: The European Space Agency)

Destination Asteroid Apophis

The 2024 north Atlantic hurricane season has started with a bang, with Hurricane Beryl traversing the whole ocean, and leaving a trail of destruction across the Caribbean, into Mexico and Texas. Presenter Roland Pease speaks to climate expert Michael Mann of Pennsylvania University about this hurricane season and the role of climate change.And Roland speaks to Amie Eisfeld of the Influenza Research Institute at the University of Wisconsin–Madison, who has been looking at the infection and transmission of bovine H5N1 influenza (bird flu). The virus is shown to be transmitted through the milk of cows with bovine flu to mice and by intranasal exposure to mice and ferrets. The findings are published in Nature this week.Ancient genomics: Neolithic farmers hit hard by the plague. Repeated outbreaks of plague may have contributed to the decline in Neolithic populations in Scandinavia, a Nature paper suggests. The analysis of ancient DNA from more than 100 individuals sheds light on the fate of these farmers around 5000 years ago. Roland speaks to geneticist Frederik Seersholm of the Lundbeck Foundation GeoGenetics Centre in Copenhagen.And a cheap coating that can be painted easily onto the glass of greenhouses converts part of the sunlight spectrum into red light that should boost the rate at which plants grow. Roland joins the chemists and crop scientists to see if there really is a difference with tomatoes and strawberries.Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production Coordinator: Jana Bennett-Holesworth (Image: Hurricane Beryl batters northern Jamaica after killing 7 people in southeast Caribbean. Credit: Anadolu/Getty Images)

Hurricane Beryl’s trail of destruction

Science in Action is at the UK's Royal Society Summer Science Exhibition, hunting for dark matter, melting ancient ice, cleaning up disused mines and looking for the batteries of the future. Presenter: Roland Pease 
Producer: Alex Mansfield 
Production Coordinator: Jana Bennett-Holesworth(Image: Pile of used batteries ready for recycling. Credit: Mindful Media via Getty Images)

Cleaner mining, cleaner batteries

An injectable antiviral "PrEP" therapy that gives 100% protection against HIV infection. Trials among young women in South Africa and Uganda proved so effective, they were wound up early to accelerate its use. Linda-Gail Bekker of the Desmond Tutu HIV Foundation shares her excitement. A new kind of gene therapy that uses the cell's own “epigenetic” mechanisms to silence troublesome portions of our DNA, tested against the prion protein responsible for some brain diseases. Jonathan Weissman led the research at the Whitehead Institute for Biomedical Research in Massachusetts. Accelerated evolution is being tested in Matthew Nitschke’s labs in the Australian Institute for Marine Science to see if it can help protect natural corals against future global warming. The amazing 4.200 km transatlantic flight of some Painted Lady butterflies – and the extraordinary detective work ecologist Gerard Talavera and team needed to prove it. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production Coordinator: Jana Bennett-Holesworth(Image: HIV Vaccine Efficacy Trial Conducted In Uganda. Credit:	Luke Dray / Stringer via Getty Images.)

On the road to halting HIV

How has China reached the top spot of scientific research so quickly? Science editor of The Economist, Ainslie Johnstone, gives us the CCPs grand, broad plans whilst senior reporter for Nature, Gemma Conroy, digs into the specifics of China’s future particle collider. Also, Gene Kirtsky, who has been studying cicadas for 50 years, discusses the spectacle of the millions of insects which have been emerging across the USA this summer. And Unexpected Elements' Marnie Chesterton gets close and personal with the stinkiest plant in the world at Kew Garden in London. 
 
Presenter: Roland Pease 
Producer: Ella Hubber
Production co-ordinator: Jana Bennett-Holesworth(Photo: Jiangmen Underground Neutrino Observatory under construction. Credit: VCG/Getty Images.)

China: Scientific superpower

With mice being the latest species to carry the disease, pandemic expert Rick Bright calls for stronger counter measures. “It’s like PTSD from February 2020” he says. The authorities in the USA are responding too slow to the spread of H5N1 bird flu through its dairy farms – even mice are carrying the virus now, and not enough is known of how it is evolving and whether humans are threatened. He talks Roland through the complex political and public health issues. Child sacrifices in the Mayan empire a thousand years ago have been confirmed with DNA evidence from bones recovered in the 1960s from an underground pit. Some victims were twins, possibly indicating a brutal ritualistic re-enactment of an ancient myth involving divine twins. Geneticist Rodrigo Barquera describes the analysis. Mature orchids perform a unique form of offspring-care, feeding tiny seedlings with nutrients via networks of thread-like fungal hyphae in the soil, according to experiments conducted at Sheffield University. Mycologist Katie Field has been delving into this underground sustenance network. Geoscientists at the edge of the Arctic ocean are looking for ancient clues to the stability of the Atlantic circulation that brings critical warmth to Europe and the northern hemisphere. Could past changes help unravel the influence of global warming? Roland talks to Renata Lucchi in the control room of Research Vessel JOIDES Resolution. Presenter: Roland Pease 
Producer: Alex Mansfield 
Production Co-ordinator: Jana Bennett-Holesworth(Image: Mouse sitting on grain. Credit: SAEED KHAN/Getty Images)

US bird flu response warning

The ‘origami’ superpowers of a single-celled pond hunter, it hunts by launching a neck-like proboscis that can extend more than 30 times its body length. Manu Prakash of Stanford University reveals the amazing mathematical mechanisms of the protist, Lacrymaria olor.It’s a microbe-eat-microbe world out there, with bacteria waging constant war against each other. It’s by dipping into their ever-evolving chemical arsenal that we keep our pharmacies supplied with the antibiotics we use to fight infectious bacteria - and computer biologist Luis Coelho of Queensland University of Technology has turned to genetics and AI to speed up the search for novel compounds.Research from Elana Hobkirk at Durham University has found that the process of domestication and selective breeding has limited the ability of domestic dogs to use facial expressions to convey emotions as effectively as their wolf ancestors. Whilst we may be easily manipulated by the ‘puppy eyes’ of our pet dogs, they are no longer able to display the same range of emotions that wolves can, who need strong visual communication to maintain their packs.Who discovered the first black hole? Science writer Marcus Chown tells us about the discovery of Cygnus X-1 discovered by Paul Murdin and Louise Webster in 1971.And 100 years ago this week, Indian physicist Satyendra Nath Bose posted his revolutionary paper to Albert Einstein, which went on to influence quantum mechanics, low-temperature physics, atomic physics, and the physics of the particles that shape the Universe. Physicist Ajoy Ghatak and presenter Roland Pease discuss the story of the man who had the word ‘boson’ coined to memorialise him in the late 1920s.Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production Coordinator: Jana Bennett-Holesworth

A humungous temporary tentacle

AI is already being used in every branch of science, and will become more and more a feature of future breakthroughs. But with its power to find subtle patterns in massive data sets comes a concern about how we will know when to trust its outcomes, and how to rely on its predictions. Science in Action talks to Alison Noble who just completed a Royal Society report on trust in scientific AI.With highly pathogenic bird flu infecting around 70 dairy herds across 10 states in the USA, including a herd of alpacas, we get an update from health journalist Helen Branswell of StatNews on the latest science and efforts to get on top of the infection.Also, from the pioneers of the mRNA vaccines that helped turn around the COVID pandemic, an experimental version that could be rolled out rapidly if the bird flu does cross worryingly into people. University of Pennsylvania’s Scott Hensley described how it works, and how promising it looks.Science in Action also hears how Europe’s new EarthCARE satellite, equipped to peer deep inside clouds, will tackle one of the biggest unknowns in the science of global warming.Presenter: Roland Pease
Producer: Jonathan Blackwell

Trusting AI with science

Fentanyl is a powerful morphine substitute, but it is also incredibly addictive – millions struggle with weaning themselves off it. And of the 600,000 drug deaths worldwide each year, the World Health Organisation estimates 80% are due to opioids in general, with synthetic opioids like fentanyl being a growing part of the problem. New work with genetically manipulated mice suggests that fentanyl affects two parts of the brain, one associated with the high, but also another that regulates fear. This knowledge could aid in the development of treatments to reduce addiction to the opioid. Early developers: Long before a developing implants into a mother's uterus, in fact as the fertilised egg divides for the first time into a pair of cells, which line becomes the future baby and which will become the 'life support' system of the placenta has been decided. Embryologist Magdalena Zernicka-Goetz explains why this early unfolding of the genetic programme is important, and why it's taken so long to discover it. Getting through pregnancy is only the first step in a person’s life. Surviving childhood, particularly for our old stone age ancestors, was the next challenge. And a new study looking at children’s teeth found at ancient archaeological sites gives clues as to why our ancestors fared better than the neanderthals around them during the last ice age. Supersense: twitching hairs on some caterpillars turn out to be early-warning sensors feeling the electric field of an approaching wasp, giving the potential prey precious moments to hide or escape death. Biophysicist Daniel Robert explains the challenge of seeing the electric world of insect hunters and hunted. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production co-ordinator: Jana Bennett-Holesworth (Image: Fentanyl. Credit: Isaac Lee via Getty Images.)

The roots of fentanyl addiction

They were the best northern and southern lights in decades, but why? And what’s next? We hear from astrophysicist Steph Yardley about the solar maximum, geomagnetic storms and atmospheric spectaculars.Also, the impossible heatwave in the Philippines made possible by global warming – the analysis of a continent-spanning climate extreme by the World Weather Attribution collaboration.Getting close up to raging tornadoes in order to fill in the big gaps that remain in the science of their development.And the tale of the lizard’s tail, and how it could lead to safer buildings in the future. (Photo: The aurora borealis, also known as the 'northern lights’, are seen over The Roaches near Leek, Staffordshire, Britain, May 10, 2024. Credit: Carl Recine/Reuters)Presenter: Roland Pease
Producer: Jonathan Blackwell

Aurora Bore-WOW-lis

Could future blood transfusions be made safer by mixing in a new bacterial enzyme? Every year 118 million blood donations need to be carefully sorted to ensure the correct blood types go to the right patients. Prof Martin Olsson, of Lund University in Sweden, and colleagues in Denmark have published a study that suggests an enzyme made by bacteria in our gut could edit our blood cells to effectively convert type A, B and AB to type O. This would be a step towards a universal blood type that could be given to any patient. Papua New Guinea’s Naomi Longa is a “Sea Woman of Melanesia”. She works to train local women from the Kimbe Bay region of the Coral Triangle to dive, snorkel, navigate and use AI to monitor the coral reefs there. She is winner of this year’s Whitley Award, and tells us why it is socially and scientifically useful to get locals - specifically females - involved in conservation efforts there. Data scientist and roboticist Prof Daniele Rus of MIT has been using Machine Learning to decipher structure in a vast swath of Sperm Whale song data from Dominica. They have discovered a set of patterns and rules of context that seem to govern the way sperm whales structure their distinctive sets of clicks. The next step? See if we can decode any semantic content… Also, 200 years after Beethoven’s 9th symphony premiered, science says its composer couldn’t hold a beat. A cautionary tale of the hubris of genetic data miners, Laura Wesseldijk describes to Roland how she and her collaborators designed the paradoxical study to point out the limitations of finding any sort of “musical genius” genes with contemporary techniques. Presenter: Roland Pease 
Producer: Alex Mansfield
Production Coordinator: Jana Bennett-Holesworth(Image: Two Sperm Whales, Caribbean Sea, Dominica. Credit: Reinhard Dirscherl via Getty Images)

Changing blood types and whale grammar

As bird flu is found in US farm cats fed on raw cow’s milk, chimpanzees are observed eating infected bat dung instead of vegetables. There is a constant threat of infections crossing from species to us and also from species to other species, particularly because of what we do. That is, after all, what happened to start the pandemic.We hear about the ongoing struggles of the Chinese virologist who broke his instructions in China in order to share the first COVID genetic data.And a strange tale of how tobacco growing might provide bat viruses a path into other species.Presenter: Roland Pease
Producer: Alex Mansfield
Production co-ordinator: Jana Bennett-HolesworthImage: Cows on an American cattle farm (Credit: Adam Davis/EPA-EFE/REX/Shutterstock)

Crossover infections

Friday, April 13th 2029 – mark it in your calendar. That’s the day an asteroid the size of an aircraft carrier will fly past Earth, closer than some satellites. Don’t worry – it will miss, but it’ll will pass so close to Earth that it will be visible to the naked eye of 2 billion people, particularly in North Africa and Western Europe.Roland Pease this week attended the Apophis T-5 Years conference at the European Space Research and Technology Centre (ESTEC) in the Netherlands, meeting astronomers scrambling to get missions up to the object to learn what kind of threats such asteroids might pose to us in the future and to discuss the science of planetary defence. NASA’s OSIRIS-APEX, a follow-on to OSIRIS-REx, will study the physical changes due to the gravitational forces from the Earth as it closely passes us by. But will there be an armada of spacecraft sent to monitor Apophis? The European Space Agency hope to gather support for their own mission, RAMSES.Presenter: Roland Pease
Producer: Jonathan BlackwellImage Credit: JPL/Caltech

An armada for asteroid Apophis?

A black hole just discovered in our Milky Way galaxy, weighing 33 times the mass of the Sun, and dating back to near the time of the Big Bang, gives new clues to the origins of this dark astronomical mysteries. And dancing with a Sun-like star in our galactic neighbourhood, it offers a great opportunity for astronomers to take a detailed look in coming years, as astronomer Professor Gerry Gilmore of Cambridge University tells the programme. Presenter Roland Pease has headed to the lab of Professor Ludovic Orlando in Toulouse, France where they are extracting ancient DNA from horses as part of a project called “Horsepower” - to reveal how our prehistoric ancestors tamed and domesticated these powerful animals (long after cattle and sheep) and in the process helped shape the extraordinary history of the first states of China and Mongolia. 
 
And a deep look into the mechanisms of addiction – showing how drugs of abuse, such as cocaine, hijack the neuronal pathways that had evolved to drive our innate needs such as eating and drinking. Roland hears from psychiatrist Eric J. Nestler of the Friedman Brain Institute at Icahn School of Medicine at Mount Sinai in New York, how this could one day improve addiction treatments. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production Coordinator: Jana Bennett-Holesworth (Image: An artist's impression shows the orbits of the most massive stellar black hole in our galaxy, dubbed Gaia BH3, and a companion star. Credit: European Southern Observatory via Reuters)

Unexpected black hole in our galaxy

The highly pathogenic strain of bird flu, H5N1, has arrived on the continent. Australian bird specialist Megan Dewar, from the Federation University of Australia, has led a mission aboard the research ship the Australis. Science in Action remembers physicist Peter Higgs 60 years after his Nobel prize winning theory of the Higgs particle. The unfolding scandal of manipulated data behind claims of incredible room-temperature superconductivity. Science writer Dan Garisto has seen the details in a Rochester University internal investigation. And the alga – single-celled seaweed – with superpowers. As well as capturing carbon from CO2 in the atmosphere, like other plants, this one can directly capture nitrogen too, essential for life, but which few organisms can do for themselves. We hear from the marine scientist who has revealed this evolutionary trick. Presenter: Roland Pease 
Producer: Jonathan Blackwell 
Production Coordinator: Jana Bennett-Holesworth (Image: KAPPA-FLU team selecting skua carcasses for post-mortem examination. Credit: Ben Wallis)

Bird flu in Antarctica

A powerful earthquake hit Taiwan on Wednesday morning, but thanks to the country’s early warning system and engineering-preparedness, there was little destruction and few deaths. Seismologist Ross Stein, CEO of earthquake consultancy Temblor, Inc., shares his analysis. 
 
The highly pathogenic bird flu H5N1 has been detected in cattle in the US and in a cattle handler in Texas. To learn more about this special animal-to-human transmission, Roland speaks to virologist Richard Webby of St. Jude Children’s Research Hospital in Tennessee and Director of the World Health Organization Collaborating Center for Studies on the Ecology of Influenza in Animals. 
 
French Space Institute Supaero in Toulouse is collaborating with Japan’s space agency JAXA to send and land a rover on Phobos, one of Mars’ tiny moons. Roland travels to the University of Toulouse to learn more about building this wheeled Rover from Supaero’s Naomi Murdoch. Transitioning to a clean energy future requires mining materials like rare earth minerals, but how will this impact our environment? Jessi Junker of the ecology charity ReWild explains her research and concerns for great apes as mining for these materials expands in Africa. Presenter: Roland Pease 
Producers: Roland Pease, Ella Hubber, Jonathan Blackwell 
Researcher: Imaan Moin 
Production Coordinator: Jana Bennett-Holesworth (Photo: Damaged building caused by the earthquake in Hualien on April 4, 2024. Credit: SAM YEH/AFP via Getty Images)

Earthquake in Taiwan

3000 light years from Earth, a white dwarf star called T Coronae Borealis is on the brink of a “once-in-a-lifetime” explosion. Astrophysicist Bradley Schaefer is enthusiastic about the bright star set to appear in the night sky in the coming months. Professor Irving Weissman has been researching ways to restore youth using mouse models for decades. He has sewn old and young mice together to join their circulatory systems and has found that giving old mice blood from younger mice reverses some signs of ageing. In his group’s paper, the use of an antibody-based therapy has been shown to restore a declining immune system in ageing mice. Not quite the fountain of youth but potentially a key step in halting many age-related diseases. Roland gets the details from Irving and first-author Dr Jason Ross. And, in the small town of Cabrières in Southern France, producer Ella Hubber goes on the hunt for some 480-million-year-old fossils with part-time fossil prospectors Eric and Sylvie Monceret. Their latest excavation site is a gold mine of rare, soft-bodied fossils from the period during a time when this part of France was underwater. And at the South Pole. Presenter: Roland Pease 
Producer: Ella Hubber(Photo: Illustration of the northern springtime constellations of Lyra, Hercules, Corona Borealis, and Bootes. Credit: Alan Dyer/Stocktrek Images)

Star for a day

The last great "out of Arica" movement of our ancestors swept out of the northeast of the continent 74,000 years ago. Archaeologist John Kappelman of the University of Texas brings us an update to this complex tale in the form of animal carcasses. We take a trip to Oxford to meet some of postgraduate researcher Ally Morton-Hayward's archive of preserved brains. Not only is Ally shining a light on these underappreciated brains, she is also using them to unlock a rich treasure-trove of information about our ancestors and how they were preserved.How do you develop and promote a vaccine against a widespread but neglected parasite? Maria Elena Bottazzi from Baylor College of Medicine is in India promoting their latest development in creating a hookworm vaccine that works against these life-limiting childhood parasites. And, is the Chandra X-Ray Observatory at risk? In a decision that has shocked astronomers, the functioning telescope is on the chopping block because of NASA budget cuts. We hear from Belinda Wilkes of Bristol University about Chandra’s impressive history and why it should keep going. Presenter/producer: Roland Pease 
Researcher: Katie Tomsett 
Production co-ordinator: Jana Bennett-Holesworth(Image: Sunset in savannah of Africa. Credit: Anton Petrus via Getty Images)

Out of Africa

After a twelve-month set of climate records driven by global warming it is time to take stock of how we’re impacting the planet as a species. Coral biologist Kate Quigley, of the Minderoo Foundation and James Cook University, dives into the 8th mass bleaching event at the Great Barrier Reef. We explore how deadly heat stress continues to threaten this underwater paradise and induce mass sickness in the corals that call it home. 
 
Heading onto land we reunite with Mike Flannigan, Professor of Fire Science at Thompson Rivers University, after a record-breaking Canadian forest fire season in 2023 we ask if conditions are set for a repeat. And what about the human cost of these climbing temperatures? In the future 800 million outdoor workers in the tropics may be exposed to intolerable heat stress. However, Yuta Masuda, director of science at the Paul G Allen Family Foundation, advises that options for individual action may be limited for workers to protect themselves. One of the driving forces behind a record year of global warming is the now waning El Niño system. With its counterpart, La Niña, due to pick up in 2024, we ask NOAA oceanographer Mike McPhaden what to expect from this transition and if we are headed for a turbulent hurricane season. 
 
Presenter/producer: Roland Pease 
Researcher: Katie Tomsett 
Production co-ordinator: Jana Bennett-Holesworth (Photo: The McDougall Creek wildfire burns in the hills West Kelowna, British Columbia, Canada, on 17 August, 2023. Credit: Darren Hull/ AFP)

Impacts of global warming

Astronomers using the James Webb Space Telescope think they have seen the glow from the first generation of stars after the Big Bang. Newton Kavli Fellow Hannah Übler discusses. The Anthropocene is meant to mean the latest geological era in which humanity is shaping the rocks and environment of our planet. But an unexpected vote by a commission has declined the idea of making this an official definition. Roland hears from one of its leading proponents, geologist Jan Zalasiewicz, about what happened and why it matters. And, new research indicates that bumblebees can show each other how to solve puzzles too complex for them to learn on their own. Professor Lars Chittka put these clever insects to the test and found that they could learn through social interaction. How exactly did the experiment work, and what does this mean for our understanding of social insects? Reporter Hannah Fisher visits the bee lab at Queen Mary University in London. Plus, the subterranean South American snake, or rather snake-like amphibian, that feeds its hatchlings milk from specially evolved glands. Brazilian biologist Carlos Jared explains more about this species’ nurturing behaviour. Presenter: Roland Pease 
Producer: Roland Pease 
Production Coordinator: Jana Bennett-Holesworth(Photo: A portion of the GOODS-North field of galaxies, highlighting the galaxy GN-z11, which is seen at a time just 430 million years after the Big Bang. Credit: Nasa/ESA/CSA/B. Robertson (UC Santa Cruz), B. Johnson (CfA), S. Tacchella (Cambridge), M. Rieke (University of Arizona), D. Eisenstein (CfA))

The first stars in the universe

The All of Us Research Program is undergoing the herculean task of gathering genomic data from over one million people living in the United States, from widely different backgrounds, in the hopes of accelerating health care research. However, within the scientific community many, including Ewan Birney, deputy director general of the European Molecular Biology Laboratory, are concerned that the way some of this data has been framed in a recent paper could reinforce racist beliefs. We also learn about the program and hear a response to the criticism from Josh Denny, the CEO of the All of Us Research Program. Over the past two years, a deadly version of bird flu, H5N1, has been spreading around the globe, killing hundreds of thousands of birds and mammals in the process. Isolated from the rest of the world, animals in Antarctica have been safe from the virus so far. But, virologist Antonio Alcamí, who is located on the continents Spanish base, confirms that bird flu has reached them, infecting Antarctic skua seabirds. And, on a less serious note, can the smell of a female cause premature death? Maybe in mice. Researcher Mike Garratt goes over the intriguing results in his new mouse study. Presenter: Roland Pease 
Producer: Ella Hubber 
Production co-ordinator: Jana Bennett-Holesworth(Image: Colorful diverse crowd in modern collage. Credit: Dedraw Studio via Getty Images)

One million genomes in two dimensions

A monumental Covid vaccine safety study of 99 million vaccinated people confirms just how rare adverse effects are and combats growing vaccine misinformation. Co-director of the Global Vaccine Data Helen Network goes through the results of this massive study. This week, Science in Action is bringing you not one, but two extraordinary astronomical discoveries. First, Webb Fellow Olivia Jones on the star hidden in the heart of only supernova visible from Earth. Second, astrophysicist Samuel Lai on what is possibly the brightest object in our universe – a whopping 500tn times brighter than our sun – a star eating quasar. And Roland chats with biologist Charlotte Houldcroft who was one of the first to blow the whistle on an absurd, AI generated image which somehow made it through the peer review process.Presenter: Roland Pease 
Producer: Ella Hubber 
Production Coordinator: Jana Bennett-Holesworth(Image: A health worker injects a man with a shot of the Inavac vaccine for Covid-19. Credit: BAY ISMOYO/AFP via Getty Images)

Largest ever covid safety study

High-profile climate scientist Michael Mann has been embroiled in a 12-year battle against conservative commentators who claimed his data was fraudulent. Last week, he was awarded $1m in a defamation lawsuit. Michael joins Science in Action to discuss the case and the impact it may have. Also, this week, Karyn Rode from the US Geological Survey has been using cameras on collars to track polar bear movement and diet. She tells Roland how the data reveals the devastating effect of sea ice loss on the bears. Widescale blackouts in Africa, known as loadshedding, are getting worse. Chemist and winner of The Royal Society Rising Star Africa Prize 2023, Wade Peterson, has an innovative chemical solution to the problem. And using a forest to detect the most violent astrophysical sources in our universe? Physicist Steven Prohira thinks it’s possible. Presenter: Roland Pease 
Producer: Ella Hubber 
Production Coordinator: Jana Bennett-Holesworth(Image: Dr. Michael E. Mann is seen outside of the H. Carl Moultrie Courthouse on February 5, 2024 in Washington, DC. Credit: Pete Kiehart for The Washington Post via Getty Images)

Climate scientist wins defamation case

Should CERN be spending $17 billion on a new atom smasher whilst we face, climate change, the most pressing crisis of our time? Materials-turned environmental scientist Mark Miodownik and CERN physicist Kate Shaw debate the issue. One of the issues Mark argues more people should be tackling are the climate change driven forest fires which recently ravaged Chile and killed more than 100 people. Chilean climate scientist Raul Cordero discusses the factors which led to the devastating fires. And Nasa physicist and oceanographer Susanne Craig explains their freshly launched satellite PACE, which hopes to get a better picture of our changing oceans and use this information to tackle climate change. A quest Nasa manages to achieve whilst also trying to answer the big questions about our universe. Presenter: Roland Pease 
Producer: Ella Hubber 
Production co-ordinator: Jana Bennett-Holesworth(Photo: Firefighters work at the Botanical Garden after a forest fire in Viña del Mar, Chile, 4 February, 2024. Credit: Javier Torres/AFP)

Particle physics v climate change

Starting upbeat this week, engineer Teddy Tzanetos, team lead of NASA’s Ingenuity mission, talks on the Mars-based helicopter which defied all expectations. 
 
Our big story this week is on the scientific papers and research databases which contain the DNA profile of thousands of people from persecuted ethnic minorities in China. This data is often collected in association with security forces. Computational biologist and campaigner Yves Moreau now leads the call for scrutiny and the retraction of these papers and databases, which lack evidence of free and informed consent. 
 
We often cover the ever-growing threat of bird flu to mammalian populations on Science in Action. But how does the virus make the successful leap from bird to mammal cells? Virologist Wendy Barclay discusses the potential tricks the virus uses to adapt and grow. And, finally, zoologist Sam Fabian has been trying to answer the question everyone thinks they already know: why are moths attracted to artificial light? Presenter: Roland Pease 
Producer: Ella Hubber 
Production Coordinator: Jana Bennett-Holesworth(Image: Protest in Urumqi in China's far west Xinjiang province on July 7, 2009. Credit: PETER PARKS/AFP via Getty Images)

Unethical data gathering in China

Molecular biologist Prof Jason Chin tells us about his research into accelerated evolution and how it could help create new substances to be used in medicine, chemistry and more. In South America, palaeogeneticist Dr Verena Schuenemann has been extracting genetic material from human remains to find out more about treponemal diseases, which include syphilis, yaws and bejel. And moving across the Atlantic to the Mediterranean, volcanologist Professor Timothy Druitt has discovered new evidence of a massive volcano that erupted beneath the sea near Santorini around 500,000 years ago. Staying in the Mediterranean, we speak to Professor Rachel Flecker, co-chief scientist on Expedition 401 of the International Ocean Discovery Program. She and her team are drilling down into the seabed to establish how the Gibraltar Strait has altered over time. As well as influencing the Mediterranean's salinity, this changing movement of water has impacted the entire planet's oceans and climate. Presenter: Roland Pease 
Producer: Alice Lipscombe-Southwell 
Production co-ordinator: Jana Bennett-Holesworth(Image Credit: Thomas Ronge)

Drilling into the past

African swine fever has now reached Southeast Asia.This part of the world has high diversity in wild pigs, some of which are endemic to their native islands. In Borneo, pigs are a hugely important food source for indigenous populations, and are a vital prey species for many big cats. In some regions, the pig populations have now dropped by 90 to 100 per cent due to swine fever. Conservationist Dr Erik Meijaard explains what this could mean for Borneo. Sticking with diseases, the World Mosquito Program breeds mosquitoes infected with Wolbachia. Why? Because mosquitoes infected with this bacteria are unable to become carriers of dengue, Zika and other mosquito-borne diseases. Dr Scott O'Neill of the World Mosquito Program talks about their latest research and the massive mosquito factory they're building in Brazil this year. Finally this week, Dr Nitzan Gonen discusses her new study, where mouse testes organoids have been grown in the lab. She tells us about the potential applications for this research. Presenter: Roland Pease 
Producer: Alice Lipscombe-Southwell 
Production co-ordinator: Jana Bennett-Holesworth(Photo: Bornean bearded pig. Credit: Sylvain Cordier/Getty Images)

Swine fever in South East Asia

The James Webb Space Telescope has revealed the clearest ever view of the stunning Cassiopeia A supernova, complete with a weird feature called 'the green monster'. Professor Dan Milisavljevic, an astronomer at Purdue University, tells us all about his research into this space-based beauty. Professor Tamara Davis from the University of Queensland has been turning her eye to far more distant supernovas, and explains how they have given us new insight into the Universe's expansion. Moving on to human history, William Barrie from the University of Cambridge tells us about a new study that explores the reason for high levels of multiple sclerosis in northern Europe. And going further back in time, researcher Ethan Mooney has studied a sample of fossilised skin, which may be the oldest ever discovered. Presenter: Roland Pease 
Producer: Alice Lipscombe-Southwell 
Editor: Martin Smith 
Production co-ordinator: Jana Bennett-Holesworth(Photo: Cassiopeia A Supernova. Credit: Nasa, ESA, CSA, STScI, Danny Milisavljevic, Purdue University, Ilse De Looze, UGent, Tea Temim, Princeton University)

Seeking supernovas

In this episode of Science in Action, we find out that tuberculosis (TB) is the leading cause of death in South Africa. After visiting a clinic dedicated to the diagnosis and treatment of TB, Roland Pease meets researcher Professor Grant Theron at Stellenbosch University, who explains why the disease is still so prevalent. Next we hear from Professor Novel Chegou and his student Candice Snyders, also based at Stellenbosch University. They are researching biomarkers to diagnose tuberculosis and have already successfully developed a rapid finger-prick test to identify TB. Roland then chats to vaccine researcher Professor Thomas Scriba at the University of Cape Town, who reveals more about the current landscape of TB vaccination. Presenter: Roland Pease 
Producer: Ella Hubber 
Editor: Martin Smith 
Production co-ordinator: Jana Bennett-Holesworth(Photo: Frontline healthcare workers wear a protective mask and tb mask to prevent the spread of airborne disease. Credit: stockstudioX/Getty Images)

Tackling tuberculosis in South Africa

In this special episode of Science in Action, Roland Pease travels to South Africa to gain a deeper understanding of human origins. Along the way, he speaks to ichnologist Charles Helm and national parks ecologist Mike Fabricius, who take him to a special – and extremely windy – location, where early human footprints are permanently preserved in the rock.
 
At the University of Cape Town, Roland speaks to Rieneke Weij and Georgina Luti. They are studying the geochemistry of rocks that existed in caves alongside our ancient relatives. Across the city, in the Iziko South African Museum, Wendy Black and Amy Sephton discuss the ways in which we think about our deep past and how we can decolonise the human story. Presenter: Roland Pease 
Producer: Ella Hubber 
Editor: Martin Smith 
Production co-ordinator: Jana Bennett-Holesworth 
 
(Image: Human fossilized footprint in hardened mud or clay. Credit: Waltkopp/Getty Images)

Following in the footsteps of ancient humans

This week, the Reykjanes volcano in Iceland has erupted, following weeks of seismic activity. Edward Wayne Marshall, from the University of Iceland, brings us the latest science about the volcano. Also this week, the UK's 40-year-old JET fusion facility has been switched off. Roland Pease went along to watch. Fusion facilities are trying to create clean energy by replicating the processes in the Sun. And the Sun itself is currently approaching solar maximum, which means we may get to enjoy more spectacular auroras but could also experience widespread radio blackouts. Solar physicist Dibyendu Nandi, from the Centre of Excellence in Space Sciences in Kolkata, tells us more. And in the outer reaches of our Solar System, the iconic Voyager 1 craft has started sending back nonsense data. William Kurth, who has worked on Voyager since its launch in 1977, reveals his personal and scientific connection to the mission. Presenter: Roland Pease 
Producer: Alice Lipscombe-Southwell 
Editor: Martin Smith 
Production Co-ordinator: Jana Bennett-Holesworth (Image: Volcano Erupts On Iceland's Reykjanes Peninsula. Credit: Micah Garen/Getty Images)

Volcanic eruption lights up Iceland

An international team of researchers led by the University of Cambridge’s Prof Stephen O’Rahilly have discovered that sensitivity to the hormone GDF15 may cause severe morning sickness during pregnancy. Dr Marlena Fejzo, who took part in the study, tells us more. Back in September, the OSIRIS-REx craft dropped a sample from the asteroid Bennu into the Utah desert. Now, scientists around the world have started studying the dust fragments in earnest. We join Dr Ashley King from the Natural History Museum in London and beamline scientist Dr Sharif Ahmed as they embark on their research. Professor Scott Fendorf, from the University of Stanford, reveals that wildfire smoke contains heavy metals, which may be why it’s so damaging to our health. Dr Junjie Yao from Duke University has worked on a new 'sono-ink'. This ink can be used to 3D print structures within the body, which can be used to mend tissues, bones and organs. Presenter: Roland Pease 
Producer: Alice Lipscombe-Southwell 
Editor: Martin Smith 
Production Co-ordinator: Jana Bennett-Holesworth (Photo: Young pregnant woman, 35 years old, feeling sick on a toilet. Credit: Getty Images)

The science of morning sickness

The burning of fossil fuels releases the greenhouse gas CO2. Many countries at COP28 have expressed an interest in using carbon capture technology to permanently capture and store this CO2. Climate and energy expert Dr Richard Black tells us more about this technology and how helpful it is in the fight against climate change. Sticking with COP28, Dr Manjana Milkoreit, from the University of Oslo, contributed to this week’s Global Tipping Points report, which revealed the Earth could be racing toward a set of critical thresholds that will put the Earth into a new state. Dr Joyce Kimutai is also at COP28. Originally from Kenya, she’s the lead author of a new paper from World Weather Attribution. The paper found that climate change has made deadly rainfall in East Africa up to two times more intense. And finally, this week Professor Dany Azar published a paper in Current Biology that not only identified the oldest fossilised mosquito, but also found that it was a male with blood-sucking mouthparts – a trait only seen in female mosquitoes today. Presenter: Roland Pease 
Producer: Alice Lipscombe-Southwell 
Editor: Martin Smith 
Production Co-ordinator: Jana Bennett-Holesworth (Image: TBC. Credit: TBC / Getty Images)